Document Detail

Intrauterine growth restriction in a low-income country: Risk factors, adverse perinatal outcomes and correlation with current WHO Multicenter Growth Reference.
MedLine Citation:
PMID:  20576369     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine risk factors and adverse perinatal outcomes including nutritional status in the first week of life for newborns with intrauterine growth restriction-low birth weight (IUGR-LBW) in settings lacking facilities for routine intrauterine growth monitoring.
METHODS: A cross-sectional study of all infants in an inner-city hospital in Lagos, Nigeria. IUGR-LBW was defined as full-term (gestational age> or =37 weeks) infant with low birth weight (<2500g). Nutritional/growth status at enrolment was determined by z-scores for length-for-age (HAZ), head circumference-for-age (HCZ), weight-for-age (WAZ) and weight-for-length (WHZ) based on current World Health Organization's Multicentre Growth Reference (WHO-MGR). Factors and adverse outcomes associated with IUGR-LBW were explored with multivariable logistic regression analyses.
RESULTS: Some 145 (4.3%) infants were IUGR-LBW out of 2619 eligible singletons enlisted for this study. IUGR-LBW was significantly associated with teenage mothers (OR:2.90, 95% CI:1.22-6.89), lack of antenatal care (OR:1.88, 95% CI:1.33-2.65) and female gender (OR:1.38, 95% CI: 0.98-1.93; p=0.062). The incidence of adverse outcomes across gestational age showed significant linear trend only for low five-minute Apgar scores (p=0.024) and WAZ (p=0.065). IUGR-LBW was associated with poor nutritional status across all four indices (p<0.001) as well as low 5-minute Apgar scores (p=0.095), sepsis (p=0.053), hyperbilirubinemia (p<0.001) and admission into special care baby unit (p=0.009) after multivariable logistic regression analyses.
CONCLUSIONS: IUGR-LBW correlates with poor nutritional status in the first week of life based on WHO-MGR and affected infants can be detected early for effective surveillance in resource-poor settings. Improved prenatal care among teenage mothers is necessary for reducing IUGR-LBW burden.
Bolajoko O Olusanya
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Publication Detail:
Type:  Journal Article     Date:  2010-06-23
Journal Detail:
Title:  Early human development     Volume:  86     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Ltd. All rights reserved.
Department of Community Health and Primary Care, University of Lagos, Idiaraba, Surulere, Nigeria.
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MeSH Terms
Apgar Score
Body Size
Cross-Sectional Studies
Fetal Growth Retardation / epidemiology*,  pathology
Gestational Age
Infant, Low Birth Weight / growth & development*
Infant, Newborn
Nutritional Status
Prenatal Care
Risk Factors
World Health Organization*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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