Document Detail


Intrauterine growth restriction: implications for placental metabolism and transport. A review.
MedLine Citation:
PMID:  19144403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrauterine growth restriction (IUGR) correlates with a specific placental phenotype, associated with defects in placental transport functions, that lead to fetal undernutrition. Both placental metabolism and transport may be affected, thus modifying the normal supply of nutrients. Models to investigate placental function may either couple or separate metabolism and transport. In human pregnancies, nutrient concentrations can be measured at the time of delivery or at cordocentesis in the umbilical vessels connecting the fetus to the placenta. The kinetics of placental transport can be evaluated in vivo using stable isotopes, i.e. infusing (13)C labelled nutrient in the mother by bolus or steady state techniques prior to cordocentesis or cesarean section. In vitro studies, using the model of the dually perfused human placenta or investigating the activity of transporters in the placental membranes have also significantly contributed to our understanding of placental function. In IUGR, the placental supply of amino acids is significantly reduced independently from the severity of growth restriction and from the presence of hypoxia. Moreover, maternal-fetal gradients of glucose are increased in severe IUGR fetuses, i.e. those with alterations of umbilical blood flows, and reduced conversion ratios of long chain-polyunsaturated fatty acids (LC-PUFA) from their parent fatty acids have been demonstrated. This review summarizes the current knowledge about placental metabolism and transport in IUGR pregnancies and the relationship with severity of the disease.
Authors:
I Cetin; G Alvino
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-01-13
Journal Detail:
Title:  Placenta     Volume:  30 Suppl A     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S77-82     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, University of Milan, 20151 Milano, Italy. irene.cetin@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Biological Transport
Fatty Acids / metabolism
Female
Fetal Growth Retardation / metabolism*
Fetus / metabolism*
Humans
Oxygen Consumption
Phenotype
Placenta / metabolism*,  physiopathology
Pregnancy / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids

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