Document Detail


Intrauterine growth restriction due to uteroplacental vascular insufficiency leads to increased hypoxia-induced cerebral apoptosis in newborn piglets.
MedLine Citation:
PMID:  16808906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Uteroplacental vascular insufficiency in humans is a common cause of intrauterine growth restriction (IUGR) and is associated with an increased incidence of perinatal asphyxia and neurodevelopmental disorders compared to normal weight newborns. Experimental models that provide an opportunity to analyze the pathogenesis of these relationships are limited. Here, we used neonatal pigs from large litters in which there were piglets of normal birth weight (for controls) and of low birth weight (for uteroplacental vascular insufficiency). Hypoxia was induced in paired littermates by reducing the fraction of inspired oxygen to 4% for 25 min. Brain tissue was collected 4 h post-hypoxia. Cerebral levels of apoptosis were quantified morphologically and verified with caspase-3 activity and TUNEL. Expression of Bcl-2, Bcl-XL and Bax proteins was investigated using immunohistochemistry. Cellular positivity for Bcl-2 was consistently higher in the non-apoptotic white matter of the hypoxic IUGR animals compared with their littermates and reached significance at P < 0.05 in several pairs of littermates. Alterations in Bax showed a trend towards higher expression in the hypoxic IUGR littermates but rarely reached significance. The IUGR piglets showed a significantly greater amount of apoptosis in response to the hypoxia than the normal weight piglets, suggesting an increased vulnerability to apoptosis in the IUGR piglets.
Authors:
Christopher Burke; Kate Sinclair; Gary Cowin; Stephen Rose; Betty Pat; Glenda Gobe; Paul Colditz
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Publication Detail:
Type:  Journal Article     Date:  2006-06-30
Journal Detail:
Title:  Brain research     Volume:  1098     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-28     Completed Date:  2006-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM    
Affiliation:
Centre for Perinatal Research, School of Medicine, University of Queensland, Herston, Australia. christeph@bigpond.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Apoptosis / physiology*
Body Weight / physiology
Brain / pathology
Cell Count
Female
Fetal Growth Retardation / physiopathology*
Frontal Lobe / pathology
Genes, bcl-2 / physiology
Hypoxia, Brain / etiology*,  pathology*
Immunohistochemistry
In Situ Nick-End Labeling
Ischemia / physiopathology
Liver / pathology
Organ Size / physiology
Placenta / blood supply*
Pregnancy
Regional Blood Flow / physiology
Swine
Thalamus / pathology
Uterus / blood supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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