Document Detail


Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisal.
MedLine Citation:
PMID:  21418379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
According to the 'small baby syndrome hypothesis' low birth weight and intrauterine growth restriction (IUGR), occurring in 'westernized' countries mainly through altered placental flow, have been linked to increased metabolic syndrome risk in later life. Independency and causal mechanisms of this phenomenological association are a matter of controversy. By means of epidemiological as well as experimental methods, using meta-analyses and different rodent models of pre- and/or neonatal malnutrition and altered placental flow (uterine artery ligation; Lig) we systematically addressed the phenomenon. Our data and systematic literature analysis revealed that neither epidemiological nor experimental evidence seems to exist linking prenatal underfeeding, low birth weight, IUGR, or decreased placental flow in rats (Lig-model) as independent risk factors to increased metabolic syndrome risk in later life. Rather, pre- and/or neonatal overfeeding, elevated birth weight, rapid neonatal weight gain, and especially increased adiposity during critical periods of perinatal life may increase long-term risks. Perinatally acquired microstructural and epigenomic alterations of regulatory systems of metabolism and body weight seem to be critical, leading to a 'cardiometabolic' risk disposition throughout life. While, e. g., experimental data in Lig-offspring seem to be considerably biased, prenatal stress and postnatal overfeeding/rapid neonatal weight gain might be causally linked to a long-term deleterious outcome in growth restricted newborns. From a clinical point of view, prevention of causes of IUGR as well as avoidance of perinatal overnourishment might be prophylactic approaches to avoid perinatal programming of 'cardiometabolic' risks.
Authors:
Uta Neitzke; Thomas Harder; Andreas Plagemann
Related Documents :
15539879 - In utero meconium suctioning may prevent meconium aspiration.
14499819 - Epidemiology of refractive errors and presbyopia.
21401709 - Mother's body mass index as a predictor of infant's nutritional status in a the post-em...
21366129 - Racial and ethnic disparity in male preterm singleton birth.
21470259 - Perinatal outcomes in native chinese and chinese-american women.
21288999 - Prevalence of wasting among under 6-month-old infants in developing countries and impli...
223489 - Cytomegalovirus isolation from a human inner ear.
1590869 - Cardiopulmonary resuscitation in very low birthweight infants.
17462489 - Evidence supporting early nutritional support with parenteral amino acid infusion.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons Ltd.
Affiliation:
Clinic of Obstetrics, Division of 'Experimental Obstetrics', Charité-University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of Dietary Soy Isoflavones in Pregnancy on Fetal Programing of Endothelial Function in Offspr...
Next Document:  Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting...