Document Detail

Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisal.
MedLine Citation:
PMID:  21418379     Owner:  NLM     Status:  Publisher    
According to the 'small baby syndrome hypothesis' low birth weight and intrauterine growth restriction (IUGR), occurring in 'westernized' countries mainly through altered placental flow, have been linked to increased metabolic syndrome risk in later life. Independency and causal mechanisms of this phenomenological association are a matter of controversy. By means of epidemiological as well as experimental methods, using meta-analyses and different rodent models of pre- and/or neonatal malnutrition and altered placental flow (uterine artery ligation; Lig) we systematically addressed the phenomenon. Our data and systematic literature analysis revealed that neither epidemiological nor experimental evidence seems to exist linking prenatal underfeeding, low birth weight, IUGR, or decreased placental flow in rats (Lig-model) as independent risk factors to increased metabolic syndrome risk in later life. Rather, pre- and/or neonatal overfeeding, elevated birth weight, rapid neonatal weight gain, and especially increased adiposity during critical periods of perinatal life may increase long-term risks. Perinatally acquired microstructural and epigenomic alterations of regulatory systems of metabolism and body weight seem to be critical, leading to a 'cardiometabolic' risk disposition throughout life. While, e. g., experimental data in Lig-offspring seem to be considerably biased, prenatal stress and postnatal overfeeding/rapid neonatal weight gain might be causally linked to a long-term deleterious outcome in growth restricted newborns. From a clinical point of view, prevention of causes of IUGR as well as avoidance of perinatal overnourishment might be prophylactic approaches to avoid perinatal programming of 'cardiometabolic' risks.
Uta Neitzke; Thomas Harder; Andreas Plagemann
Related Documents :
12521409 - Primary postpartum haemorrhage.
15612379 - Rehabilitation of infants with osteogenesis imperfecta.
22214879 - Electrophysiological measurements and analysis of nociception in human infants.
20165999 - usefulness of probiotics in prevention and therapy
21446229 - Head ultrasonograhy as a screening tool in apparently healthy asymptomatic term neonates.
2611119 - Comparative study of alginate and non-alginate antacids concurrently administered with ...
17087539 - In search of shared and nonshared environmental factors in security of attachment: a be...
1182379 - Fertility of the sibs of schizophrenic patients.
20684179 - How to evaluate the child presenting with an apparent life-threatening event?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-10
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons Ltd.
Clinic of Obstetrics, Division of 'Experimental Obstetrics', Charité-University Medicine Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of Dietary Soy Isoflavones in Pregnancy on Fetal Programing of Endothelial Function in Offspr...
Next Document:  Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting...