Document Detail

Intrauterine growth and postnatal skeletal development: findings from the Southampton Women's Survey.
MedLine Citation:
PMID:  22150706     Owner:  NLM     Status:  MEDLINE    
We have previously demonstrated associations between fetal growth in late pregnancy and postnatal bone mass. However, the relationships between the intrauterine and early postnatal skeletal growth trajectory remain unknown. We addressed this in a large population-based mother-offspring cohort study. A total of 628 mother-offspring pairs were recruited from the Southampton Women's Survey. Fetal abdominal circumference was measured at 11, 19 and 34 weeks gestation using high-resolution ultrasound with femur length assessed at 19 and 34 weeks. Bone mineral content was measured postnatally in the offspring using dual-energy X-ray absorptiometry at birth and 4 years; postnatal linear growth was assessed at birth, 6, 12, 24, 36 and 48 months. Late pregnancy abdominal circumference growth (19-34 weeks) was strongly (P < 0.01) related to bone mass at birth, but less robustly associated with bone mass at 4 years. Early pregnancy growth (11-19 weeks) was more strongly related to bone mass at 4 years than at birth. Postnatal relationships between growth and skeletal indices at 4 years were stronger for the first and second postnatal years, than the period aged 2-4 years. The proportion of children changing their place in the distribution of growth velocities progressively reduced with each year of postnatal life. The late intrauterine growth trajectory is a better predictor of skeletal growth and mineralisation at birth, while the early intrauterine growth trajectory is a more powerful determinant of skeletal status at age 4 years. The perturbations in this trajectory which influence childhood bone mass warrant further research.
Nicholas C Harvey; Pam A Mahon; Miranda Kim; Zoe A Cole; Sian M Robinson; Kassim Javaid; Hazel M Inskip; Keith M Godfrey; Elaine M Dennison; Cyrus Cooper;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  26     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-04-26     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  34-44     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
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MeSH Terms
Body Composition / genetics
Body Height / physiology
Bone Density / physiology*
Bone Development / physiology*
Bone and Bones / physiology*
Child Development / physiology
Child, Preschool
Cohort Studies
Fetal Development / physiology*
Great Britain
Prospective Studies
Regression Analysis
Young Adult
Grant Support
MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1017//Medical Research Council; RG/07/009/23120//British Heart Foundation; SP/02/003/14542//British Heart Foundation; U.1475.00.004.00002.01(74221)//Medical Research Council; //Arthritis Research UK; //British Heart Foundation; //Medical Research Council
P Taylor / ; L J Greenaway / ; M Hanson / ; D J P Barker / ; C M Law / ; C E Nisbet /

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