Document Detail


Intrauterine growth and childhood leukemia and lymphoma risk.
MedLine Citation:
PMID:  23146059     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Leukemias and lymphomas account for nearly half of all childhood cancers. Although there have been major advances in the treatment of these diseases, what causes them remains largely unknown. There is strong evidence to suggest that leukemia originates in utero, and early life factors may play a role in its etiology. A series of reports illustrate a convincing link between the rate of intrauterine growth and the risk of childhood leukemia. Some studies suggest that this risk relationship also extends to non-Hodgkin lymphoma in children, although, overall, the association with childhood lymphoma is less clear. This review discusses the intricacies of these risk relationships and explores potential explanations of how the rate of fetal growth may influence cancer risk.
Authors:
Kate A O'Neill; Kathryn J Bunch; Michael Fg Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of hematology     Volume:  5     ISSN:  1747-4094     ISO Abbreviation:  Expert Rev Hematol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485942     Medline TA:  Expert Rev Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  559-76     Citation Subset:  IM    
Affiliation:
The Childhood Cancer Research Group, Richards Building, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LG, UK.
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