Document Detail

Intrauterine fetal demise can be remote from the inciting insult in an animal model of hypoxia-ischemia.
MedLine Citation:
PMID:  22580720     Owner:  NLM     Status:  Publisher    
Background:Fetal hypoxia-ischemia results in significant morbidity and mortality. Little is known about the timing of death in human stillbirths. The vulnerability of the fetus varies with age at the time of insult but it is unknown what happens to the timing of fetal death in relation to a fetal insult. We asked the question whether the timing of fetal death was influenced by the age at which the insult occurred.Methods:Fetal hypoxia-ischemia was achieved at three ages by sustained uterine ischemia in rabbits, mimicking the acute placental insufficiency of placental abruption.Results:Hypoxia-ischemia at 22 days gestation (E22) resulted in less perinatal deaths than at E25 and E29. Fetal deaths were grouped into early and late perinatal deaths. Early perinatal death mostly occurred immediately after hypoxia-ischemia and these fetuses delivered before term. Late perinatal death occurred between the insult and delivery at term gestation. Early perinatal death occurred more often in the E25 hypoxic-ischemic group compared to those from E22.Conclusions:There is an increasing vulnerability to hypoxia with increasing gestational age. Perinatal deaths may occur long after the episode of hypoxia-ischemia. The timing of an intrauterine hypoxic-ischemic event cannot be inferred from the detection of fetal death.
Matthew Derrick; Ila Englof; Alexander Drobyshevsky; Kehuan Luo; Lei Yu; Sidhartha Tan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-11
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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