Document Detail

Intrauterine exposure to diesel exhaust diminishes adult ovarian reserve.
MedLine Citation:
PMID:  23419929     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To analyze ovarian and uterine morphologic changes resulting from intrauterine and postnatal exposure to diesel exhaust. DESIGN: Crossover study. Experimental groups: intrauterine and postnatal clean air exposure; intrauterine exposure to diesel only; postnatal exposure to diesel only; and intrauterine and postnatal exposure to diesel. SETTING: Laboratory of Experimental Air Pollution. ANIMAL(S): Swiss mice. INTERVENTION(S): Mice exposed to diesel exhaust with doses that correspond to the daily average PM(2.5) levels (fine particles in the ambient air 2.5 μm or less in size) reported by the World Health Organization. MAIN OUTCOME MEASURE(S): Morphometric analyses of the ovaries and uterus were performed to define the relative area occupied by follicles, corpus luteum, and stroma and the proportionate area of glands, epithelial layer, and stroma within the uterine endometrium. RESULT(S): A significant reduction in the proportion of primordial follicles was observed in intrauterine-exposed animals, those exposed during the postnatal period, and in animals exposed during both phases. Primary follicle proportion was reduced in animals exposed during pregnancy. No significant changes were detected in uterine morphology. CONCLUSION(S): Intrauterine exposure to acceptable levels of diesel exhaust compromises the reproductive potential of female mice, diminishing ovarian reserve when sexual maturity is achieved. This effect could increase the risk of premature menopause. The findings raise concern about current environmental guidelines for diesel exposure, warranting more careful examination of this issue in humans by regulatory authorities.
Karolyn Sassi Ogliari; Ana Julia de Faria Coimbra Lichtenfels; Mary Rosa Rodrigues de Marchi; Alice Teixeira Ferreira; Marisa Dolhnikoff; Paulo Hilario Nascimento Saldiva
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-15
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Laboratory of Experimental Air Pollution, Department of Pathology, and Laboratory of Experimental Therapeutics, University of São Paulo School of Medicine. Electronic address:
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