Document Detail

Intrauterine diagnosis and management of fetal goitrous hypothyroidism: a report of an Iranian family with three consecutive pregnancies complicated by fetal goiter.
MedLine Citation:
PMID:  16405406     Owner:  NLM     Status:  MEDLINE    
The diagnosis and treatment of hypothyroidism during the fetal period may decrease perinatal morbidity and are believed to be important to optimize growth and intellectual development. Herewith a case report of fetal goitrous hypothyroidism is presented in a euthyroid mother, detected at 34 weeks' gestation by ultrasonography, and treated with intra-amniotic levothyroxine injections. The mother had two previous consecutive pregnancies (13 and 8 years ago), also complicated by the occurrence of fetal goiter, resulting in tracheal compression, asphyxia, and early neonatal death in the first and in an emergency cesarean section delivery, because of fetal malpresentation, in the second neonate affected by congenital hypothyroidism (CH). The present male newborn, although born without observable goiter, had a large thyroid on ultrasonography and an early rise of his peripheral venous blood thyrotropin confirmed the diagnosis of CH. Low serum thyroglobulin in the proband and his older brother and parental consanguinity was mostly compatible with a thyroglobulin defective synthesis and secretion as the cause of CH and fetal goiter. Despite apparently sufficient dose of intraamniotic levothyroxine injections repeated weekly from 34-37 weeks' gestation (i.e., four injections of 500 microg levothyroxine), neonatal bone age on the second day of life showed delayed skeletal maturation.
Ali-Asghar Mirsaeid Ghazi; Arash Ordookhani; Marina Pourafkari; Masoumeh Fallahian; Adeleh Bahar; Mehdi Hedayati; Ali Hafizi; Fereidoun Azizi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  15     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-12     Completed Date:  2006-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-7     Citation Subset:  IM    
Endocrine Research Center, Taleghani Hospital, haheed Beheshti University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Bone Development
Fetal Diseases / diagnosis,  therapy*
Goiter / diagnosis,  genetics,  therapy*
Hypothyroidism / diagnosis,  genetics,  therapy*
Infant, Newborn
Prenatal Diagnosis*

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