Document Detail

Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice.
MedLine Citation:
PMID:  16894624     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A picornavirus (Ljunganvirus [LV]) has recently been associated with disease during pregnancy in its natural rodent reservoir and in humans. A study of laboratory mice infected under controlled conditions was therefore undertaken. METHODS: CD-1 female mice were infected gestational day two and subjected to varying regimes of stress. RESULTS: LV infection in combination with stress resulted in uterine resorptions, malformations, and neonatal death. A short delay in time to first pregnancy and births was observed in pairs infected in utero. CONCLUSIONS: LV is found in different species of native animals in both Europe and the United States and human epidemiological evidence connects LV and human reproduction, while the observations here indicate that LV is responsible for reproductive problems in a laboratory mouse model. The current findings suggest that the hypothesis that LV also causes disease in pregnant women and their offspring deserves further study.
Annika Samsioe; Ricardo Feinstein; George Saade; Ake Sjöholm; Birger Hörnfeldt; Reinald Fundele; William Klitz; Bo Niklasson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Birth defects research. Part B, Developmental and reproductive toxicology     Volume:  77     ISSN:  1542-9733     ISO Abbreviation:  Birth Defects Res. B Dev. Reprod. Toxicol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2006-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101155115     Medline TA:  Birth Defects Res B Dev Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital, Stockholm, Sweden.
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MeSH Terms
Congenital Abnormalities / etiology*
Fetal Death / etiology*
Mice, Inbred ICR
Picornaviridae Infections / complications*
Pregnancy Complications, Infectious
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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