Document Detail

Intrauterine administration of levonorgestrel in two low doses in HRT. A randomized clinical trial during one year: effects on lipid and lipoprotein metabolism.
MedLine Citation:
PMID:  8746877     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the effects on lipid and lipoprotein metabolism of two doses (5- or 10 micrograms/24 h) of levonorgestrel released from an intrauterine device (IUD) in combination with orally administered estradiol (2 mg estradiol valerate) in perimenopausal women. DESIGN: A 1-year prospective randomized single blind clinical trial. SETTING: Department of Obstetrics and Gynaecology, Ostra Hospital, Göteborg, Sweden. SUBJECTS: Fifty-one perimenopausal women with climacteric symptoms. OUTCOME MEASURES: Cholesterol in serum and in lipoprotein fractions; high-density lipoprotein (HDL), low-density lipoprotein (LDL). Triglycerides in serum and in very low-density lipoprotein. RESULTS: In both treatment groups significant elevations in HDL-cholesterol of similar magnitude were observed after 1 month and these changes were maintained during the 12 month observation period. In both treatment groups an initial significant decrease of LDL-cholesterol was observed and the decrement was maintained after 12 months. Serum levels of cholesterol decreased significantly in both groups after 1 month and were maintained after 12 months in the levonorgestrel-IUD (LNG-IUD) 5 micrograms group. However, the initial reduction of serum cholesterol in the LNG-IUD 10 micrograms group did not differ from baseline after 12 months. Serum triglyceride levels fluctuated during the observation period. No significant changes occurred. CONCLUSION: Continuous combined HRT with intrauterine administration of levonorgestrel, 5- or 10 micrograms/24 h, in perimenopausal women was observed to increase HDL-cholesterol and to decrease LDL-cholesterol compared with pretreatment values. The low doses of levonorgestrel did not reverse the beneficial effects on lipid metabolism usually seen after estradiol administration.
L O Wollter-Svensson; E Stadberg; K Andersson; L A Mattsson; V Odlind; I Persson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Maturitas     Volume:  22     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  199-205     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital of Uppsala, Sweden.
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MeSH Terms
Administration, Oral
Cholesterol / blood
Climacteric / blood,  drug effects*
Drug Therapy, Combination
Estradiol / administration & dosage,  analogs & derivatives
Estrogen Replacement Therapy*
Estrogens, Conjugated (USP) / administration & dosage
Intrauterine Devices, Medicated*
Levonorgestrel / administration & dosage*,  adverse effects
Lipids / blood*
Lipoproteins / blood*
Middle Aged
Prospective Studies
Triglycerides / blood
Reg. No./Substance:
0/Estrogens, Conjugated (USP); 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 50-28-2/Estradiol; 57-88-5/Cholesterol; 797-63-7/Levonorgestrel; 979-32-8/estradiol valerate

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