Document Detail


Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization in neonatal pigs.
MedLine Citation:
PMID:  20335628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonates with intrauterine growth restriction (IUGR) are prone to suffer from digestive diseases. Using neonatal pigs with IUGR, we tested the hypothesis that IUGR may induce alterations in the developmental pattern of intestinal barrier and thereby may be responsible for IUGR-associated increased morbidity. Piglets with a birth weight near the mean birth weight (+/-0.5 SD) were identified as normal birth weight (control) and piglets with a mean -2 SD lower birth weight (-30%) were defined as piglets with IUGR. The developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization was investigated from birth to d 5 postnatal. At birth, intestinal weight and length, ileal and colonic weight per unit of length, and villous sizes were lower (P < 0.05) in piglets with IUGR than in same-age control piglets. These IUGR-induced intestinal alterations further persisted, although they were less marked at d 5. Counts of adherent bacteria to ileal and colonic mucosa were greater (P < 0.05) in 2-d-old piglets with IUGR than in same-age control piglets. Dynamic analyses of the transcriptomic profile of the intestine revealed molecular evidence of IUGR-induced intestinal growth impairment that may result from a change in the cell proliferation-apoptosis balance during the first days of life, while a protective process would occur later on. In addition, changes in the expression of several genes suggest a pivotal role of both glucocorticoids and microbiota in driving IUGR intestinal development during the neonatal period.
Authors:
Romain D'Inca; Maela Kloareg; Christ?le Gras-Le Guen; Isabelle Le Hu?rou-Luron
Related Documents :
18615088 - Growth and neurodevelopment at 16 to 24 months of age for infants born with gastroschisis.
3948588 - Effects of atypical patterns of fetal growth on newborn (nbas) behavior.
2690628 - Clinical management of the fetus with markedly diminished umbilical artery end-diastoli...
16006428 - Maternal fish oil supplementation in lactation and growth during the first 2.5 years of...
12721728 - A prospective study of neonatal inguinal herniotomy: the problem of the postoperative h...
18978168 - Intrauterine growth restriction and zinc concentrations in term infants during the firs...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-24
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-21     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  925-31     Citation Subset:  IM    
Affiliation:
INRA, UMR 1079, SENAH, F-35590 Saint-Gilles, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Apoptosis
Bacteria / growth & development*
Birth Weight
Cell Proliferation
Fetal Growth Retardation / physiopathology*
Gene Expression
Gene Expression Profiling*
Gene Expression Regulation, Developmental
Glucocorticoids
Intestinal Mucosa / embryology,  growth & development*,  microbiology
Intestines / embryology,  growth & development*,  microbiology
Organ Size
RNA / metabolism
Swine
Chemical
Reg. No./Substance:
0/Glucocorticoids; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optimal Dietary True Ileal Digestible Threonine for Supporting Mucosal Barrier in the Small Intestin...
Next Document:  Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese W...