Document Detail

Intrauterine growth restriction and the innate immune system in preterm infants of ≤32 weeks gestation.
MedLine Citation:
PMID:  23295537     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Intrauterine growth restriction (IUGR) is a well-known cause of adverse neonatal outcomes. As it may have an impact on innate immune responses, we aimed to investigate several parameters of the innate immune response in preterm infants of ≤32 weeks gestation who were small for gestational age (SGA).
METHODS: We compared clinical data of SGA (n = 20) and appropriate for gestational age (AGA; n = 124) newborns with a gestational age of ≤32 weeks. We investigated full blood counts at birth and on days 3 and 7 of life and cytokine immune responses in a human whole cord blood assay.
RESULTS: SGA preterm infants had a higher risk of the combined outcome mortality or bronchopulmonary dysplasia. Numbers of white blood cells and neutrophils were diminished in SGA infants at birth and on day 3. At birth, platelet counts were also diminished while the number of nucleated red blood cells tended to be elevated in SGA infants. After stimulation of whole blood cell cultures with lipopolysaccharides, the concentrations of interleukin-6 and interleukin-10 were significantly lower in SGA preterm infants compared to AGA infants.
CONCLUSIONS: SGA infants differ remarkably from AGA infants in full blood counts and in their ability to mount an immune response. Whether the quantitative deficiency in innate immunity plays a role for adverse outcomes needs to be investigated in larger future trials.
Birte Tröger; Thilo Müller; Kirstin Faust; Meike Bendiks; Michael K Bohlmann; Susanne Thonnissen; Egbert Herting; Wolfgang Göpel; Christoph Härtel
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Publication Detail:
Type:  Journal Article     Date:  2012-12-22
Journal Detail:
Title:  Neonatology     Volume:  103     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-03     Completed Date:  2013-08-08     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
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MeSH Terms
Bronchopulmonary Dysplasia / immunology,  mortality
Case-Control Studies
Cells, Cultured
Erythrocyte Count
Fetal Blood / immunology
Fetal Growth Retardation / blood,  immunology*,  mortality
Gestational Age
Immunity, Innate* / drug effects
Infant Mortality
Infant, Newborn
Infant, Premature*
Interleukin-10 / metabolism
Interleukin-6 / metabolism
Leukocyte Count
Lipopolysaccharides / pharmacology
Neutrophils / immunology
Odds Ratio
Platelet Count
Regression Analysis
Risk Assessment
Risk Factors
Time Factors
Reg. No./Substance:
0/IL10 protein, human; 0/IL6 protein, human; 0/Interleukin-6; 0/Lipopolysaccharides; 130068-27-8/Interleukin-10

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