Document Detail


Intrauterine growth restriction delays feeding-induced gut adaptation in term newborn pigs.
MedLine Citation:
PMID:  20881437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neonates born after intrauterine growth restriction (IUGR) show higher mortality and morbidity and greater feeding problems postnatally.
OBJECTIVES: We tested the hypothesis that IUGR affects the intestinal structure, function, microbiology and proinflammatory cytokine expression during the immediate neonatal period.
METHODS: We firstly compared organ weights and intestinal digestive enzyme activities between control and IUGR newborn piglets delivered by cesarean section at full term or prematurely (91% gestation). Next, we compared intestinal structure, function and microbiota in spontaneously delivered control and IUGR term piglets during the period 0-5 days of age, when intestinal adaptation is normally very rapid.
RESULTS: At the time of birth, organ weights and intestinal enzyme activities were not notably affected by IUGR, neither for preterm nor term pigs, except that IUGR was associated with a relatively long and thin intestine. Between birth and 5 days of age, the normal developmental pattern in the ileum and colon appeared to be delayed in term IUGR piglets, as indicated by lower ileal density (weight per unit length) and villous area (-20 to -30%), higher expression of the peptide transporter PEPT1 (+150% on day 2) and enhanced bacterial adhesion and translocation during days 2-5 (all p < 0.05). Further, expression of the proinflammatory cytokine IL-6 was modified in the intestine of term IUGR piglets at birth without any change in IL-1β.
CONCLUSION: IUGR is associated with a longer and thinner intestine at birth, and during the immediate postnatal period, intestinal adaptation and bacterial colonization are altered in IUGR piglets born at full term.
Authors:
Romain D'Inca; Christèle Gras-Le Guen; Lianqiang Che; Per T Sangild; Isabelle Le Huërou-Luron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-25
Journal Detail:
Title:  Neonatology     Volume:  99     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-30     Completed Date:  2011-08-03     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  208-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Animals, Newborn
Birth Weight
Colony Count, Microbial
Female
Fetal Growth Retardation / metabolism*,  microbiology
Gastrointestinal Tract / enzymology,  metabolism*,  microbiology
Histocytochemistry
Laccase / metabolism
Peptide Hydrolases / metabolism
Pregnancy
RNA / chemistry,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Sucrase / metabolism
Swine
Symporters / genetics,  metabolism*
alpha-Glucosidases / metabolism
Chemical
Reg. No./Substance:
0/PepT1 protein; 0/Symporters; 63231-63-0/RNA; EC 1.10.3.2/Laccase; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.48/Sucrase; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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