Document Detail

Intrauterine exposure to tobacco and risk of medically indicated and spontaneous preterm birth.
MedLine Citation:
PMID:  20013584     Owner:  NLM     Status:  MEDLINE    
We investigated the association between prenatal smoking and the occurrence of medically indicated and spontaneous preterm delivery (<37 weeks). We performed a retrospective cohort study of singleton live births in the state of Missouri (n = 1,219,159) using maternally linked cohort data files covering the period 1989 to 2005. The main outcomes of interest were spontaneous and medically indicated preterm and very preterm birth. Logistic regression models were used to generate adjusted odds ratios and their 95% confidence intervals. There were 132,246 (10.8%) infants born preterm in the study population, of which 106,410 (80.5%) were classifiable as spontaneous preterm births and 25,836 (19.5%) were medically indicated preterm deliveries. We found elevated risks for both medically indicated and spontaneous preterm birth associated with maternal cigarette smoking during pregnancy. This heightened risk was particularly evident for medically indicated preterm birth (adjusted odds ratio [95% confidence interval] = 1.48 [1.41 to 1.55]). Women who smoke during pregnancy are at increased risk for preterm birth, and especially for medically indicated preterm delivery.
Muktar H Aliyu; O'Neil Lynch; Rakiya Saidu; Amina P Alio; Phillip J Marty; Hamisu M Salihu
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Publication Detail:
Type:  Journal Article     Date:  2009-12-10
Journal Detail:
Title:  American journal of perinatology     Volume:  27     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-10     Citation Subset:  IM    
Copyright Information:
Copyright Thieme Medical Publishers.
Department of Preventive Medicine and Vanderbilt Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA.
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MeSH Terms
Gestational Age
Infant, Newborn
Missouri / epidemiology
Pregnancy Outcome
Premature Birth / epidemiology*,  etiology*
Retrospective Studies
Smoking / adverse effects*
Tobacco / adverse effects*

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