Document Detail

Intratympanic administration of methylprednisolone reduces impact of experimental intensive impulse noise trauma on hearing.
MedLine Citation:
PMID:  18815936     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The present findings demonstrated that intratympanic methylprednisolone (MP) reduces the impact of impulse noise trauma on hearing and in part preserves the hair cells from death 1 h after exposure to intensive impulse noise. OBJECTIVE: To examine the treatment efficiency of intratympanic MP (IT-MP) with different methods of administration on cochlear injury induced by exposure to intensive impulse noise. MATERIALS AND METHODS: Fifty-five guinea pigs were assigned into six groups and exposed to intensive impulse noise, i.e. 60 impulses at 165 dB SPL peak pressure with 0.5 ms duration and 2 s intervals. The auditory brainstem response (ABR) was used to examine the hearing thresholds. Cochlear morphology was examined to estimate the inner and outer hair cell loss induced by impulse noise exposure. MP was applied as a rescue agent via different modalities of administration. RESULTS: The ABR threshold value of IT-MP1 or IT-MP4 groups significantly decreased at 4 weeks as compared with the IT-NS (IT 0.9% physiological saline) group. The ABR threshold value of the group that received intramuscular administration of MP (IM-MP) also decreased at 4 weeks as compared with the IT-NS group. Significant hair cell loss was observed at the region 40-50% from the apex in the present model. Within this region, the residual hair cell number in the IT-MP1 or IT-MP4 groups was significantly greater than that in the IT-NS group.
Yide Zhou; Hongliang Zheng; Xiaohua Shen; Qing Zhang; Meiqin Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  129     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-15     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  602-7     Citation Subset:  IM    
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
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MeSH Terms
Cochlea / cytology,  pathology
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
Glucocorticoids / administration & dosage
Guinea Pigs
Hair Cells, Auditory / drug effects,  pathology
Hearing Loss, Noise-Induced / diagnosis,  prevention & control*
Injections / methods
Labyrinth Diseases / diagnosis,  prevention & control*
Methylprednisolone / administration & dosage*
Neuroprotective Agents / administration & dosage
Tympanic Membrane
Reg. No./Substance:
0/Glucocorticoids; 0/Neuroprotective Agents; 83-43-2/Methylprednisolone

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