Document Detail

Intratubal methotrexate for prevention of persistent ectopic pregnancy after salpingotomy.
MedLine Citation:
PMID:  12386357     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To investigate whether frequency of persistent ectopic pregnancy after linear salpingotomy can be reduced by prophylactic administration of a single intraoperative injection of local methotrexate. DESIGN: Prospective, randomized, controlled trial (Canadian Task Force classification I). SETTING: University-affiliated hospital. PATIENTS: Sixty-five women with unruptured ectopic pregnancy. INTERVENTION: Laparoscopic salpingotomy with or without a single intratubal dose of methotrexate 1 mg/kg. MEASUREMENTS AND MAIN RESULTS: In the prophylaxis group, 22 patients received a single dose of intratubal methotrexate 1 mg/kg after linear salpingotomy; 43 controls had only linear salpingotomy. Six women (14%) in the control group developed persistent ectopic pregnancy, compared with none in the prophylaxis group (p <0.05). CONCLUSION: In our opinion, intratubal methotrexate injection during laparoscopic salpingotomy is a practical option for women with unruptured ectopic pregnancy.
Hakan Kaya; Yasemin Babar; Sadik Ozmen; Okan Ozkaya; Mehmet Karci; Ali Riza Aydin; Demir Ozbasar
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of the American Association of Gynecologic Laparoscopists     Volume:  9     ISSN:  1074-3804     ISO Abbreviation:  J Am Assoc Gynecol Laparosc     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-18     Completed Date:  2003-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9417443     Medline TA:  J Am Assoc Gynecol Laparosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-7     Citation Subset:  IM    
Departments of Obstetrics and Gynecology, University of Süleyman Demirel, Isparta 32040, Turkey.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Combined Modality Therapy
Fallopian Tube Patency Tests
Fallopian Tubes / drug effects*
Follow-Up Studies
Injections, Intralesional
Methotrexate / administration & dosage*
Pregnancy, Ectopic / diagnosis,  drug therapy,  surgery
Pregnancy, Tubal / diagnosis,  drug therapy*,  surgery*
Primary Prevention / methods
Prospective Studies
Recurrence / prevention & control
Reference Values
Salpingostomy / adverse effects,  methods*
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

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