| Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits. | |
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MedLine Citation:
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PMID: 18204151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Local administration of corticosteroids may diminish acute lung injury associated with meconium aspiration. Budesonide was given intratracheally in 2 doses of 0.25 mg/kg each by means of inpulsion effect of high-frequency jet ventilation 0.5 and 2.5 hours after meconium instillation to oxygen-ventilated adult rabbits. Within 5 hours after the first dose, budesonide significantly improved gas exchange and decreased right-to-left pulmonary shunts, central venous pressure, and ventilatory pressures. In addition, budesonide reduced the meconium-induced lung edema formation, airway hyperreactivity to histamine, count of neutrophils in bronchoalveolar lavage fluid associated with higher total white blood cell and neutrophil counts in the blood, and diminished oxidative modifications of proteins and lipids in lung tissue compared to non-treated meconium-instilled group. The intratracheally administered corticosteroid budesonide effectively improved pulmonary functions and alleviated changes associated with inflammation in meconium-instilled rabbits. |
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Authors:
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D Mokra; J Mokry; A Drgova; M Petraskova; J Bulikova; A Calkovska |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 58 Suppl 5 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-01-21 Completed Date: 2008-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 389-98 Citation Subset: IM |
Affiliation:
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Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. mokra@jfmed.uniba.sk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage* Animals Bronchial Provocation Tests Bronchoconstriction / drug effects Bronchoconstrictor Agents / administration & dosage Budesonide / administration & dosage* Central Venous Pressure / drug effects Disease Models, Animal Histamine / administration & dosage Humans Infant, Newborn Intubation, Intratracheal Lipid Peroxidation / drug effects Lung / drug effects*, metabolism, physiopathology Meconium Aspiration Syndrome / drug therapy*, metabolism, physiopathology Neutrophil Infiltration / drug effects Oxidative Stress / drug effects Pneumonia, Aspiration / metabolism, physiopathology, prevention & control* Protein Carbonylation / drug effects Pulmonary Circulation / drug effects Pulmonary Edema / physiopathology, prevention & control Pulmonary Gas Exchange / drug effects Pulmonary Ventilation / drug effects Rabbits Respiratory System Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Bronchoconstrictor Agents; 0/Respiratory System Agents; 51-45-6/Histamine; 51333-22-3/Budesonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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