| Intratracheal administration of endotoxin and cytokines. VII. The soluble interleukin-1 receptor and the soluble tumor necrosis factor receptor II (p80) inhibit acute inflammation. | |
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MedLine Citation:
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PMID: 8020186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intratracheal administration of endotoxin (LPS) causes acute neutrophilic inflammation via induction of pulmonary tumor necrosis factor alpha (TNF) and interleukin-1 (IL-1) expression. In the present study, the anti-inflammatory activity of soluble IL-1 receptor (sIL-1r) and soluble TNF receptor p80 (sTNFr-p80) in LPS-induced acute pulmonary inflammation was investigated. The sIL-1r coinjected intratracheally with LPS in rats significantly inhibits neutrophilic exudation into bronchoalveolar lavage (BAL) fluid by 47% after 6 hr compared to injection of LPS alone. TNF and IL-6 in the same BAL fluids were both lowered by approximately 50% after intratracheal coinjection of sIL-1r and LPS as compared to LPS alone. In the same model, the sTNFr-p80 inhibited acute inflammation. Paradoxically, TNF levels in BAL fluids were generally elevated after the intratracheal coinjection of LPS and monomeric sTNFr-p80 compared to injection of LPS injection alone. The combined anti-inflammatory effect of sIL-1r and sTNFr-p80 at the maximally effective individual doses is not significantly greater than the effect of either soluble receptor alone. |
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Authors:
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T R Ulich; E S Yi; S Yin; C Smith; D Remick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 72 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1994-07-29 Completed Date: 1994-07-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-40 Citation Subset: IM |
Affiliation:
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Department of Pathology, San Diego School of Medicine, University of California. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchoalveolar Lavage Fluid / immunology Endotoxins / administration & dosage, antagonists & inhibitors* Inflammation / immunology, prevention & control* Interleukin-6 / biosynthesis Intubation, Intratracheal Lipopolysaccharides / antagonists & inhibitors Male Rats Rats, Inbred Lew Receptors, Interleukin-1* Receptors, Tumor Necrosis Factor* Recombinant Proteins / administration & dosage, pharmacology Solubility Tumor Necrosis Factor-alpha / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Interleukin-6; 0/Lipopolysaccharides; 0/Receptors, Interleukin-1; 0/Receptors, Tumor Necrosis Factor; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha |
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