Document Detail

Intratracheal N-acetylcysteine use in infants with chronic lung disease.
MedLine Citation:
PMID:  1606395     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of intratracheal administration of N-acetylcysteine (Mucomyst) on the clinical status, pulmonary function and gas exchange in premature infants with chronic lung disease, we conducted a randomized, placebo-controlled, crossover trial. Ten mechanically ventilated infants (gestational age 27 +/- 1 week; postnatal age 22 +/- 6 days) with clinical and radiological evidence of chronic lung disease and increased airway secretion were enrolled in the study. Each infant received tracheal administration of 5% N-acetylcysteine for one week and saline placebo every 4 h for another week. N-acetylcysteine was associated with a 59 +/- 26% increase in total airway resistance by the third day of treatment (p less than 0.01). A two-fold increase in airway resistance associated with an increased frequency of bradycardia and cyanosis spells was seen in two of the infants following three days of N-acetylcysteine administration, with a rapid improvement in their condition when subsequently switched to saline. Overall, N-acetylcysteine administration had no effect on the variables measured. We conclude that intratracheal administration of N-acetylcysteine to liquefy airway mucus neither improves the clinical condition nor hastens recovery in premature infants with chronic lung disease and its administration may lead to increased total airway resistance and cyanotic spells. The present data do not support the use of N-acetylcysteine as a mucolytic agent in premature infants with chronic lung disease.
H Bibi; B Seifert; M Oullette; J Belik
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  81     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Department of Pediatrics, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Acetylcysteine / administration & dosage*,  adverse effects,  therapeutic use
Airway Resistance / drug effects
Chronic Disease
Infant, Newborn
Infant, Premature*
Instillation, Drug
Intubation, Intratracheal
Lung Compliance / drug effects
Lung Diseases / drug therapy*,  physiopathology
Lung Volume Measurements
Prospective Studies
Pulmonary Gas Exchange / drug effects
Respiration, Artificial
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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