Document Detail

Intrathoracic extravasation of antineoplastic agents: case report and systematic review.
MedLine Citation:
PMID:  12714879     Owner:  NLM     Status:  MEDLINE    
A case history is presented of a 34-year-old woman who was treated postoperatively for breast cancer with combination chemotherapy including epirubicin. The catheter of the port penetrated the wall of the superior vena cava, and extravasation in the mediastinum occurred. Severe pain, fever, and bilateral pleural effusion developed that necessitated two drainage procedures. She recovered well without sequelae. A comprehensive search of the medical literature was conducted using MEDLINE including bibliographies of all selected articles. Six additional cases of intrathoracic cytostatic agent extravasation were identified and the etiologic factors, clinical course, treatment strategy, and outcome were reviewed for each case.
A Kürşat Bozkurt; Burak Uzel; Canan Akman; Mustafa Ozgüroğlu; Nil Molinas Mandel
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  26     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-25     Completed Date:  2003-05-06     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  121-3     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*,  therapeutic use
Breast Neoplasms / drug therapy*,  surgery
Catheters, Indwelling / adverse effects*
Combined Modality Therapy
Contrast Media
Epirubicin / administration & dosage
Extravasation of Diagnostic and Therapeutic Materials* / complications,  diagnosis,  therapy
Hydrothorax / etiology
Pleural Effusion / etiology
Subclavian Vein
Tomography, X-Ray Computed
Vena Cava, Superior
Reg. No./Substance:
0/Contrast Media; 56420-45-2/Epirubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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