| Intrathoracic Pressure Regulation Improves 24-Hour Survival in a Pediatric Porcine Model of Hemorrhagic Shock. | |
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MedLine Citation:
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PMID: 21646939 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hemorrhagic shock is a common cause of mortality and morbidity in the pediatric population. Intrathoracic pressure regulation (IPR) lowers intrathoracic pressure thereby decreasing intracranial pressure and increasing venous return, cardiac output, and cerebral perfusion without the need for immediate fluid resuscitation. We hypothesized that IPR would improve hemodynamics and 24-hour survival in a pediatric porcine model of hemorrhagic shock. Twenty piglets were subjected to a 50% total blood volume hemorrhage over 15 minutes and then randomized to treatment with either IPR or no treatment. After 60 minutes, survivors were auto-transfused, weaned from the ventilator and assessed and autopsied at 24 hours. Mean arterial pressures (MAP), cardiac index (CI), and arterial blood gases were recorded. MAP (mmHg) was significantly higher in the IPR group (60.8 ± 3.7) vs. controls (41.2 ± 4.6, p<0.01). Mean CI (L/min/m) was significantly higher with IPR (3.9 ± 0.24) vs. controls (2.5 ± 0.39, p<0.01). IPR survival rates were significantly improved with the IPR (9/9 (IPR) vs 5/11 (controls); p<0.02). In this piglet model of hemorrhagic shock, the IPR treatment safely and significantly improved MAP, CI and 24 hour survival rates. ABBREVIATIONS: |
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Authors:
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Anja Metzger; Timothy Matsuura; Scott McKnite; Bradley S Marino; Vinay M Nadkarni; Demetris Yannopoulos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-3 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Emergency Medicine [A.M.], Department of Cardiology [D.Y.], University of Minnesota, Minneapolis, MN 55455; Department of Research [A.M., T.M.], Advanced Circulatory Systems, Inc., St. Paul, MN 55113; Department of Research [S.M.], Minneapolis Medical Research Foundation, Minneapolis, MN 55455; Department of Pediatrics [B.S.M.], Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229; Department of Anesthesia, Critical Care, and Pediatrics [V.M.N.], The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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