| INTRATHECAL NEUROTENSIN IS HYPOTENSIVE, SYMPATHOINHIBITORY AND ENHANCES THE BAROREFLEX IN ANAESTHETISED RAT. | |
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MedLine Citation:
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PMID: 22035146 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and purpose. The neuromodulatory effects of the gut-neuropeptide neurotensin on sympathetic vasomotor tone, central respiratory drive and adaptive reflexes in the spinal cord, are not known. Experimental approach Neurotensin (0.5µM - 3mM) was administered into the intrathecal space at the sixth thoracic spinal cord segment in urethane anaesthetised, paralysed, vagotomised male Sprague-Dawley rats. Pulsatile arterial pressure, splanchnic sympathetic nerve activity (sSNA), phrenic nerve activity, ECG, and end-tidal CO(2) were recorded. Key results Neurotensin caused a dose-related hypotension, sympathoinhibition and bradycardia. The maximum effects were observed at 3000µM where the decreases in mean arterial pressure (MAP), heart rate (HR) and sSNA reached -25mmHg, -26bpm and -26% from baseline, respectively. The sympathetic baroreflex was enhanced. Changes in central respiratory drive were characterized by a fall in the amplitude of the phrenic nerve. Finally, administration of SR 142948A (5mM), a potent, selective antagonist at neurotensin receptors, caused a potent hypotension (-35mmHg), bradycardia (-54bpm), sympathoinhibition (-44%). A reduction in the amplitude, and frequency, of phrenic nerve was also observed. Conclusions and implications The data demonstrate that neurotensin plays an important role in the regulation of spinal cardiovascular function, affecting both tone and adaptive reflexes. |
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Authors:
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B Zogovic; P M Pilowsky |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-28 |
Journal Detail:
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Title: British journal of pharmacology Volume: - ISSN: 1476-5381 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
Affiliation:
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Australian School of Advanced Medicine Macquarie University 2109 AUSTRALIA. |
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