| Intrathecal immune activation in three patients with progressive myoclonic ataxia. | |
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MedLine Citation:
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PMID: 7753063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition. |
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Authors:
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A Salmaggi; F Carella; C Ciano; S Binelli; P Giovannini; E Palazzini; F Girotti |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 10 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-21 Completed Date: 1995-06-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-10 Citation Subset: IM |
Affiliation:
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Istituto Nazionale Neurologico C. Besta, Milano, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ataxia / diagnosis, immunology* Central Nervous System / immunology* Humans Laboratory Techniques and Procedures Lymphocytes* Male Middle Aged Myoclonus / diagnosis, immunology* |
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