Document Detail

Intrathecal immune activation in three patients with progressive myoclonic ataxia.
MedLine Citation:
PMID:  7753063     Owner:  NLM     Status:  MEDLINE    
Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2- to 5-year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune-mediated damage within the central nervous system in this condition.
A Salmaggi; F Carella; C Ciano; S Binelli; P Giovannini; E Palazzini; F Girotti
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  10     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-06-21     Completed Date:  1995-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-10     Citation Subset:  IM    
Istituto Nazionale Neurologico C. Besta, Milano, Italy.
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MeSH Terms
Ataxia / diagnosis,  immunology*
Central Nervous System / immunology*
Laboratory Techniques and Procedures
Middle Aged
Myoclonus / diagnosis,  immunology*

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