Document Detail


Intrathecal drug delivery strategy is safe and efficacious for localized delivery to the spinal cord.
MedLine Citation:
PMID:  17618992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuroprotective and neuroregenerative strategies for spinal cord injury repair are limited in part by poor delivery techniques. A novel drug delivery system is being developed in our laboratory that can provide localized release of therapeutically relevant molecules from an injectable hydrogel. Design criteria were established for the hydrogel to be--injectable, fast-gelling, biocompatible, biodegradable and able to release biologically active therapeutics when injected into the intrathecal space that surrounds the spinal cord. This novel way of localized drug delivery to the spinal cord was tested first with a collagen gel and then with a new hydrogel blend of hyaluronan and methylcellulose (HAMC). The underlying principle that this novel methodology is both safe and able to provide localized delivery was proven with a fast gelling collagen solution. Using a recombinant human epidermal growth factor, rhEGF, dispersed in collagen, we demonstrated localized release to the injured spinal cord. We extended this technology to other fast-gelling systems and found that HAMC was injectable due to the shear thinning property of hyaluronan (HA), biocompatible and had some therapeutic benefit when injected into the intrathecal space using a compression injury model in rats.
Authors:
Molly S Shoichet; Charles H Tator; Peter Poon; Catherine Kang; M Douglas Baumann
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in brain research     Volume:  161     ISSN:  0079-6123     ISO Abbreviation:  Prog. Brain Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376441     Medline TA:  Prog Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Donnelly Center for Cellular and Biomolecular Research, Toronto, ON, M5S 3E1, Canada. molly@ecf.utoronto.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Drug Delivery Systems
Gels
Humans
Injections, Spinal*
Neuroprotective Agents / administration & dosage*,  therapeutic use*
Spinal Cord Injuries / drug therapy*
Chemical
Reg. No./Substance:
0/Gels; 0/Neuroprotective Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vivo tracking of stem cells in brain and spinal cord injury.
Next Document:  Decompression craniectomy after traumatic brain injury: recent experimental results.