| Intrathecal drug delivery strategy is safe and efficacious for localized delivery to the spinal cord. | |
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MedLine Citation:
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PMID: 17618992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuroprotective and neuroregenerative strategies for spinal cord injury repair are limited in part by poor delivery techniques. A novel drug delivery system is being developed in our laboratory that can provide localized release of therapeutically relevant molecules from an injectable hydrogel. Design criteria were established for the hydrogel to be--injectable, fast-gelling, biocompatible, biodegradable and able to release biologically active therapeutics when injected into the intrathecal space that surrounds the spinal cord. This novel way of localized drug delivery to the spinal cord was tested first with a collagen gel and then with a new hydrogel blend of hyaluronan and methylcellulose (HAMC). The underlying principle that this novel methodology is both safe and able to provide localized delivery was proven with a fast gelling collagen solution. Using a recombinant human epidermal growth factor, rhEGF, dispersed in collagen, we demonstrated localized release to the injured spinal cord. We extended this technology to other fast-gelling systems and found that HAMC was injectable due to the shear thinning property of hyaluronan (HA), biocompatible and had some therapeutic benefit when injected into the intrathecal space using a compression injury model in rats. |
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Authors:
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Molly S Shoichet; Charles H Tator; Peter Poon; Catherine Kang; M Douglas Baumann |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in brain research Volume: 161 ISSN: 0079-6123 ISO Abbreviation: Prog. Brain Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-07-09 Completed Date: 2007-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376441 Medline TA: Prog Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 385-92 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering and Applied Chemistry, University of Toronto, Donnelly Center for Cellular and Biomolecular Research, Toronto, ON, M5S 3E1, Canada. molly@ecf.utoronto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drug Delivery Systems Gels Humans Injections, Spinal* Neuroprotective Agents / administration & dosage*, therapeutic use* Spinal Cord Injuries / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Gels; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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