Document Detail


Intrathecal baclofen alleviates autonomic dysfunction in severe brain injury.
MedLine Citation:
PMID:  10938609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sympathetic storm phenomena are well known therapeutic problems in patients with severe brain injury. We have treated four patients with intrathecal baclofen (ITB) who suffered from severe hypertension, tachycardia and other sympathetic storm phenomena after different primary events. In all patients conventional therapy with sedatives and antiadrenergic medication had been taken to the upper limits before initiating ITB. Autonomic dysfunction immediately improved in three of four patients. In all patients ITB, via lumbar or ventricular route, proved safe and without complications. The anatomical and pharmacological basis of the GABA-B agonist action on such sympathetic storm phenomena are not yet fully understood. However, the positive results observed in three out of four patients are promising and require further investigation. ITB is a new therapeutic approach to control otherwise unresponsive sympathetic storm phenomena in severe brain injury.
Authors:
R Becker; L Benes; U Sure; D Hellwig; H Bertalanffy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  7     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  316-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Affiliation:
Department of Neurosurgery, Philipps-University Hospital, Marburg, Germany.becker5@mailer.uni-marburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Autonomic Dysreflexia / drug therapy*,  pathology,  physiopathology
Autonomic Nervous System / drug effects*,  pathology,  physiopathology
Baclofen / administration & dosage*
Brain / drug effects,  pathology,  radiography
Brain Injuries / drug therapy*,  pathology,  radiography
Humans
Injections, Spinal
Intracranial Aneurysm / complications,  radiography,  surgery
Male
Rats
Chemical
Reg. No./Substance:
1134-47-0/Baclofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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