| Intratesticular islet allografts in the spontaneously diabetic BB/W rat. | |
MedLine Citation:
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PMID: 2864296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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THE RESULTS: in the absence of immunosuppression all six of the rats with abdominal, intratesticular islet allografts became normoglycemic within 2 days after transplantation but in none did graft survival exceed 17 days; a marked prolongation of graft survival of greater than 65-441 days occurred in 13 of the 15 animals with identical intratesticular allografts; sustained immunosuppression was not needed for prolonged islet allograft survival in rats with cryptorchid islet allografts; and (4) only one of the 12 rats with scrotal, intratesticular allografts became normoglycemic whereas 11 remained severely glycosuric. However, on surgical translocation of the grafted testes from the scrotum into the abdominal cavity, the rats promptly became normoglycemic in the absence of any additional therapy. |
Authors:
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H Selawry; R Fajaco; K Whittington |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 34 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-31 Completed Date: 1985-10-31 Revised Date: 2014-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1019-24 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilymphocyte Serum / pharmacology Cryptorchidism Diabetes Mellitus, Experimental / surgery* Glycosuria Islets of Langerhans Transplantation* Male Rats Rats, Inbred BB Testis / surgery* |
| Grant Support | |
ID/Acronym/Agency:
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R01-AM-20346-05/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antilymphocyte Serum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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