Document Detail


Intratesticular islet allografts in the spontaneously diabetic BB/W rat.
MedLine Citation:
PMID:  2864296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
THE RESULTS: in the absence of immunosuppression all six of the rats with abdominal, intratesticular islet allografts became normoglycemic within 2 days after transplantation but in none did graft survival exceed 17 days; a marked prolongation of graft survival of greater than 65-441 days occurred in 13 of the 15 animals with identical intratesticular allografts; sustained immunosuppression was not needed for prolonged islet allograft survival in rats with cryptorchid islet allografts; and (4) only one of the 12 rats with scrotal, intratesticular allografts became normoglycemic whereas 11 remained severely glycosuric. However, on surgical translocation of the grafted testes from the scrotum into the abdominal cavity, the rats promptly became normoglycemic in the absence of any additional therapy.
Authors:
H Selawry; R Fajaco; K Whittington
Related Documents :
2864296 - Intratesticular islet allografts in the spontaneously diabetic bb/w rat.
12396286 - Simultaneous orthotopic transplantation of carotid and aorta in the rat by the sleeve t...
8610386 - Functional activity of anti-c6 antibodies elicited in c6-deficient rats reconstituted b...
19545756 - Establishment of an acute graft-versus-host disease model following liver transplantati...
2530016 - Renal hyper-responsiveness to blood volume expansion in brattleboro rats is not related...
21376086 - Avoidance perseveration during extinction training in wistar-kyoto rats: an interaction...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  34     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-31     Completed Date:  1985-10-31     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1019-24     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antilymphocyte Serum / pharmacology
Cryptorchidism
Diabetes Mellitus, Experimental / surgery*
Glycosuria
Islets of Langerhans Transplantation*
Male
Rats
Rats, Inbred BB
Testis / surgery*
Grant Support
ID/Acronym/Agency:
R01-AM-20346-05/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lormetazepam (Loramet) in the elderly: an acceptability study.
Next Document:  Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal-model predi...