Document Detail


Intratemporal facial nerve ultrastructure in patients with idiopathic facial paralysis: viral infection evidence study.
MedLine Citation:
PMID:  20963349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: to analyze the ultrastructure of the facial nerve seeking viral evidences that might provide etiological data.
MATERIAL AND METHODS: We studied 20 patients with peripheral facial palsy (PFP), with moderate to severe FP, of both genders, between 18-60 years of age, from the Clinic of Facial Nerve Disorders. The patients were broken down into two groups - Study: eleven patients with IPFP and Control: nine patients with trauma or tumor-related PFP. The fragments were obtained from the facial nerve sheath or from fragments of its stumps - which would be discarded or sent to pathology exam during the facial nerve repair surgery. The removed tissue was fixed in 2% glutaraldehyde, and studied under Electronic Transmission Microscopy.
RESULTS: In the study group we observed an intense repair cellular activity by increased collagen fibers, fibroblasts containing developed organelles, free of viral particles. In the control group this repair activity was not evident, but no viral particles were observed.
CONCLUSION: There were no viral particles, and there were evidences of intense activity of repair or viral infection.
Authors:
Rosangela Aló Maluza Florez; Raquel Lang; Adriano Mora Veridiano; Renato de Oliveira Zanini; Pedro Luiz Calió; Ricardo Dos Santos Simões; José Ricardo Gurgel Testa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brazilian journal of otorhinolaryngology     Volume:  76     ISSN:  1808-8686     ISO Abbreviation:  Braz J Otorhinolaryngol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-21     Completed Date:  2011-02-04     Revised Date:  2011-10-04    
Medline Journal Info:
Nlm Unique ID:  101207337     Medline TA:  Braz J Otorhinolaryngol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  639-42     Citation Subset:  IM    
Affiliation:
Universidade Santa Cecília, Dentistry School of UNISANTA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bell Palsy / virology*
Facial Nerve / pathology,  ultrastructure*
Facial Paralysis / virology*
Female
Fibroblasts / ultrastructure
Humans
Male
Microscopy, Electron, Transmission
Middle Aged
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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