Document Detail

Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats.
MedLine Citation:
PMID:  18547623     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effects of intrastriatal injection of hypoxanthine, the major compound accumulated in Lesch-Nyhan disease, on performance step-down inhibitory avoidance task in the rat. Male adult Wistar rats were divided in two groups: (1) saline-injected and (2) hypoxanthine-injected group. Treated-group received intrastriatal hypoxanthine solution 30 min before training session (memory acquisition) or immediately after training session (memory consolidation) or 30 before test session (memory retrieval) on step-down inhibitory avoidance task. Results show that hypoxanthine administration caused significant memory impairment in all periods tested. These results show that intrastriatal hypoxanthine administration provoked memory process impairment of step-down inhibitory avoidance task, an effect that might be related to the cognitive memory alterations in Lesch-Nyhan patients.
Caren Serra Bavaresco; Juliana Ben; Fabria Chiarani; Carlos Alexandre Netto; Angela Terezinha Souza Wyse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  90     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-29     Completed Date:  2008-11-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-7     Citation Subset:  IM    
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Avoidance Learning / drug effects*
Basal Ganglia / physiology
Hypoxanthine / administration & dosage,  pharmacology*
Memory / drug effects*
Rats, Wistar
Stereotaxic Techniques
Reg. No./Substance:

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