| Intrastriatal hypoxanthine reduces Na(+),K (+)-ATPase activity and induces oxidative stress in the rats. | |
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MedLine Citation:
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PMID: 17226099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The main objective of this study was to investigate the effects of a single intrastriatal injection of hypoxanthine, a metabolite accumulated in Lesch Nyhan disease and possibly involved in its neuropathology, on Na(+),K(+)-ATPase activity, as well as on some parameters of oxidative stress, namely chemiluminescence (an index of lipid peroxidation), total radical-trapping antioxidant parameter--TRAP (an index of total antioxidant capacity of the tissue) and total thiol protein membrane content, in striatum, cerebral cortex and hippocampus of rats. Results show that hypoxanthine significantly decreased Na(+),K(+)-ATPase activity and TRAP while increased chemiluminescence in all ipsislateral structures tested. However, no effect on total thiol protein membrane content was detected. We suggest that hypoxanthine induces oxidative stress in all cerebral structures studied (striatum, hippocampus and cerebral cortex) and that the reduction of Na(+),K(+)-ATPase activity was probably mediated by reactive oxygen species. |
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Authors:
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Caren Serra Bavaresco; Fabria Chiarani; Clovis Milton Duval Wannmacher; Carlos Alexandre Netto; Angela Terezinha de Souza Wyse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-17 |
Journal Detail:
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Title: Metabolic brain disease Volume: 22 ISSN: 0885-7490 ISO Abbreviation: Metab Brain Dis Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-02 Completed Date: 2007-07-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600-Anexo, CEP 90035-003, Porto Alegre, RS, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Cell Membrane / enzymology Cerebral Cortex / drug effects, enzymology Corpus Striatum / drug effects, enzymology* Hippocampus / drug effects, enzymology Hypoxanthine / toxicity* Lesch-Nyhan Syndrome / metabolism* Lipid Peroxidation / drug effects, physiology Microinjections Oxidative Stress / drug effects, physiology* Rats Rats, Wistar Sodium-Potassium-Exchanging ATPase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 68-94-0/Hypoxanthine; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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