| Intrastriatal dopamine D1 receptor agonist-mediated motor behavior is reduced by local neurokinin 1 receptor antagonism. | |
| | |
MedLine Citation:
|
PMID: 15858838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent evidence suggests that striatal neurokinin receptors modulate dopamine (DA)-induced motor behaviors. To further examine this, we studied the effects of intrastriatal neurokinin 1 receptor (NK1R) antagonism on motor behaviors induced by direct infusion of the full DA D1 receptor agonist SKF 82958. Adult male Sprague-Dawley rats received bilateral intrastriatal 0.8-mul infusions of the NK1R receptor antagonist LY 306,740 (0, 27, or 54 nmol/side) followed by intrastriatal infusions of SKF 82958 (0 or 24 nmol/side) into the dorsal striatum. Following each infusion, rats were placed into automated activity monitors for the quantification of horizontal activity, total distance traveled, movement bouts, and stereotypy counts. As expected, SKF 82958 increased motor activity on all behavioral measures. More importantly, whereas 27 nmol was without effect, prior infusion of 54 nmol LY 306,740 significantly reduced most aspects of behavior. The results of this study suggest that functional NK1Rs within the striatum play a permissive role in the motor behaviors induced by D1R stimulation. |
| | |
Authors:
|
David M Krolewski; Christopher Bishop; Paul D Walker |
Related Documents
:
|
2969448 - The dopaminergic d receptor: another example of reductive activation? 8102308 - Inhibition of substantia nigra dopamine cell firing by r(-)-n-n-propylnorapomorphine: e... 7914538 - Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the ... 11223008 - Comparative effects of scopolamine and quinpirole on the striatal fos expression induce... 10396128 - U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990. 17118798 - Novel gpcr screening approach: indirect identification of s1p receptor agonists in anta... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Synapse (New York, N.Y.) Volume: 57 ISSN: 0887-4476 ISO Abbreviation: Synapse Publication Date: 2005 Jul |
Date Detail:
|
Created Date: 2005-05-03 Completed Date: 2005-07-12 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8806914 Medline TA: Synapse Country: United States |
Other Details:
|
Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
|
Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetamides
/
administration & dosage,
pharmacology Animals Benzazepines / administration & dosage, pharmacology Dopamine Agonists / administration & dosage, pharmacology* Male Microinjections Motor Activity / drug effects* Neostriatum / drug effects, metabolism* Rats Rats, Sprague-Dawley Receptors, Dopamine D1 / agonists* Receptors, Neurokinin-1 / antagonists & inhibitors* Stereotyped Behavior / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
NS39013/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Acetamides; 0/Benzazepines; 0/Dopamine Agonists; 0/LY 306740; 0/Receptors, Dopamine D1; 0/Receptors, Neurokinin-1; 80751-65-1/SK&F 82958 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region...
Next Document: Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement o...