Document Detail

Intrastriatal dopamine D1 receptor agonist-mediated motor behavior is reduced by local neurokinin 1 receptor antagonism.
MedLine Citation:
PMID:  15858838     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that striatal neurokinin receptors modulate dopamine (DA)-induced motor behaviors. To further examine this, we studied the effects of intrastriatal neurokinin 1 receptor (NK1R) antagonism on motor behaviors induced by direct infusion of the full DA D1 receptor agonist SKF 82958. Adult male Sprague-Dawley rats received bilateral intrastriatal 0.8-mul infusions of the NK1R receptor antagonist LY 306,740 (0, 27, or 54 nmol/side) followed by intrastriatal infusions of SKF 82958 (0 or 24 nmol/side) into the dorsal striatum. Following each infusion, rats were placed into automated activity monitors for the quantification of horizontal activity, total distance traveled, movement bouts, and stereotypy counts. As expected, SKF 82958 increased motor activity on all behavioral measures. More importantly, whereas 27 nmol was without effect, prior infusion of 54 nmol LY 306,740 significantly reduced most aspects of behavior. The results of this study suggest that functional NK1Rs within the striatum play a permissive role in the motor behaviors induced by D1R stimulation.
David M Krolewski; Christopher Bishop; Paul D Walker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  57     ISSN:  0887-4476     ISO Abbreviation:  Synapse     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-05-03     Completed Date:  2005-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA.
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MeSH Terms
Acetamides / administration & dosage,  pharmacology
Benzazepines / administration & dosage,  pharmacology
Dopamine Agonists / administration & dosage,  pharmacology*
Motor Activity / drug effects*
Neostriatum / drug effects,  metabolism*
Rats, Sprague-Dawley
Receptors, Dopamine D1 / agonists*
Receptors, Neurokinin-1 / antagonists & inhibitors*
Stereotyped Behavior / drug effects
Grant Support
Reg. No./Substance:
0/Acetamides; 0/Benzazepines; 0/Dopamine Agonists; 0/LY 306740; 0/Receptors, Dopamine D1; 0/Receptors, Neurokinin-1; 80751-65-1/SK&F 82958

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