Document Detail

Intrastrand locks increase duplex stability and base pairing selectivity.
MedLine Citation:
PMID:  21863176     Owner:  NLM     Status:  Publisher    
Oligodeoxynucleotide probes with disulfide locks between neighboring nucleobases show increases in melting point for duplexes with RNA target strands of up to 7.6 °C. The weakly pairing TT dimers are replaced with locked 2'-deoxy-5-(thioalkynyl)uridine residues via automated synthesis.
Cora Prestinari; Clemens Richert
Related Documents :
10885626 - Inhibition of oxidative dna damage in vitro by extracts of brussels sprouts.
9192816 - Metal ion-dependent hydrogen peroxide-induced dna damage is more sequence specific than...
10838136 - Mutations induced by reactive nitrogen oxide species in the supf forward mutation assay.
9776756 - Guanine is the target for direct ionisation damage in dna, as detected using excision e...
6579536 - Mitochondrial dna and nuclear dna from normal rat liver have a common sequence.
8388196 - Novel 1-8-bridged chiral quinolones with activity against topoisomerase ii: stereospeci...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute for Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70565 Stuttgart, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation.
Next Document:  Formation of ultracold SrYb molecules in an optical lattice by photoassociation spectroscopy: theore...