Document Detail

Intraspinal hematomas in hemophilia.
MedLine Citation:
PMID:  1530122     Owner:  NLM     Status:  MEDLINE    
We report herein a case of a intraspinal hematoma in a 9-year-old boy with factor IX deficiency. Replacement of factor IX resulted in resolution of symptoms. The most frequent presentations of intraspinal hematomas are neck or back pain, paresis, sensory impairment, and urinary retention. Intraspinal hematomas may have devastating sequelae, including hemiplegia and quadriplegia. The occurrence or development of sequelae are related to the length of time between onset of symptoms and factor replacement. Whenever the physician suspects intraspinal hematoma, immediate replacement should be given to obtain levels of 80-100% prior to any imaging studies. Factor levels should be maintained at 30-50% for 10-14 days while the patient is monitored closely with serial neurological examinations. Most patients respond to factor replacement, but laminectomy should be considered for intractable or progressive cases.
M R Hamre; J S Haller
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  14     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-10-20     Completed Date:  1992-10-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  166-9     Citation Subset:  IM    
Tulane University Medical Center, Department of Pediatrics, New Orleans, Louisiana.
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MeSH Terms
Factor IX / therapeutic use
Factor VIII / therapeutic use
Hematoma / etiology*
Hemophilia A / complications,  therapy
Hemophilia B / complications*,  therapy
Spinal Diseases / etiology*
Treatment Outcome
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX

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