Document Detail

Intrarenal vascular sites of action of adenosine and glucagon.
MedLine Citation:
PMID:  2087004     Owner:  NLM     Status:  MEDLINE    
Our purpose was to localize the intrarenal vascular sites of action of adenosine and glucagon. Renal blood flow (RBF) and glomerular filtration rate (GFR) were measured in anesthetized dogs, and renal perfusion pressure (RPP) was varied by an adjustable aortic clamp. At normal RPP, RBF was increased by all agents. In contrast, GFR was increased by glucagon, decreased by adenosine and unchanged by acetylcholine (ACh) or adenosine plus glucagon. The increases in RBF by glucagon occurred only at RPPs within the autoregulatory pressure range, and renal autoregulatory capability was attenuated during the infusion of glucagon. In contrast, adenosine increased RBF at RPPs both within and below the autoregulatory pressure range, and the autoregulatory capability was not perceptibly impaired. Superimposition of glucagon to adenosine caused further vasodilation, and the autoregulatory efficiency was completely attenuated. There was no difference between the RPP-RBF or RPP-GFR relations obtained during infusion of adenosine plus glucagon and ACh, which dilates both the afferent and efferent arterioles. It is generally accepted that afferent arteriolar resistance attains a minimum value at RPP near the lower limit of the autoregulatory range. Thus, our data indicate that glucagon and adenosine preferentially dilate the afferent arteriole and the efferent arteriole, respectively.
Y Aki; T Shoji; K Hasui; K Fukui; T Tamaki; H Iwao; Y Abe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  54     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-23     Completed Date:  1991-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
Department of Pharmacology, Kagawa Medical School, Japan.
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MeSH Terms
Adenosine / antagonists & inhibitors,  pharmacology*
Blood Pressure / drug effects*
Glomerular Filtration Rate / drug effects
Glucagon / administration & dosage,  pharmacology*
Homeostasis / drug effects
Renal Circulation / drug effects*
Reg. No./Substance:
58-61-7/Adenosine; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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