Document Detail

Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension.
MedLine Citation:
PMID:  17444274     Owner:  NLM     Status:  MEDLINE    
It is now well accepted that alterations in kidney function, due either to primary renal disease or to inappropriate hormonal influences on the kidney, are a cardinal characteristic in all forms of hypertension, and lead to a reduced ability of the kidneys to excrete sodium and the consequent development of elevated arterial pressures. However, it is also apparent that many extrarenal factors are important contributors to altered kidney function and hypertension. Central to many hypertensinogenic processes is the inappropriate activation of the renin-angiotensin system (RAS) and its downstream consequences by various pathophysiologic mechanisms. There may also be derangements in arachidonic acid metabolites, endothelium derived factors such as nitric oxide and carbon monoxide, and various paracrine and neural systems that normally interact with or provide a counteracting balance to the actions of the RAS. Thus, when the capacity of the kidneys to maintain sodium balance and extracellular fluid volume within appropriate ranges is compromised, increases in arterial pressure become necessary to re-establish normal balance.
K D Mitchell; F T Botros; L G Navar
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  94     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-05-11     Revised Date:  2008-06-11    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  31-48     Citation Subset:  IM    
Department of Physiology, Tulane Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, 1430 Tulane Ave, SL 39, New Orleans, Louisiana, LA 70112, USA.
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MeSH Terms
Angiotensin II / physiology*
Atrial Natriuretic Factor / physiology
Blood Pressure / physiology
Carbon Monoxide / physiology
Cyclooxygenase Inhibitors / pharmacology
Eicosanoids / biosynthesis
Heme / metabolism
Heme Oxygenase (Decyclizing) / physiology
Hypertension / physiopathology*
Hypertension, Renal / etiology
Renin-Angiotensin System / physiology*
Grant Support
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Eicosanoids; 11128-99-7/Angiotensin II; 14875-96-8/Heme; 630-08-0/Carbon Monoxide; 85637-73-6/Atrial Natriuretic Factor; EC Oxygenase (Decyclizing)
Comment In:
Acta Physiol Hung. 2008 Mar;95(1):127-8; author reply 129-30   [PMID:  18390005 ]

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