Document Detail

Intrarenal mechanisms that regulate sodium excretion in relationship to changes in blood pressure.
MedLine Citation:
PMID:  2512459     Owner:  NLM     Status:  MEDLINE    
Because pressure-related natriuresis may be central to the regulatory role of the kidney on blood pressure, it is important to understand the relationship of humoral systems involved in the control of renal hemodynamics and tubular function. The preglomerular endothelial synthesis of prostaglandin I2 and endothelium-derived relaxing factor seem to modulate autoregulatory control by the afferent arterioles and the release of renin by the juxtaglomerular apparatus. The release of renin is followed by an increase in angiotensin II in the renal interstitium, which is responsible for adjusting the vascular tone of the efferent arterioles and vasa recta and for stimulating proximal tubular reabsorption of sodium. Variations in medullary circulation induced by angiotensin II could alter medullary interstitial pressure and the medullary production of prostaglandins E2 and I2 and, ultimately, could modulate sodium reabsorption in the medullary thick ascending limbs and the collecting ducts.
J C Romero; M D Bentley; P M Vanhoutte; F G Knox
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  64     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1406-24     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure*
Epoprostenol / biosynthesis*
Hypertension / etiology
Kidney / physiology*
Natriuresis / physiology*
Nitric Oxide / secretion
Sodium, Dietary / metabolism
Grant Support
Reg. No./Substance:
0/Sodium, Dietary; 31C4KY9ESH/Nitric Oxide; DCR9Z582X0/Epoprostenol

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