Document Detail

Intrarenal haemodynamic and glomerular responses to inhibition of nitric oxide formation in rabbits.
MedLine Citation:
PMID:  8189388     Owner:  NLM     Status:  MEDLINE    
1. The renal effects of inhibiting nitric oxide (NO) formation using N-nitro-L-arginine (NOLA, 20 mg kg-1) were examined using micropuncture techniques in pentobarbitone-anaesthetized rabbits. 2. Renal vascular resistance doubled from 2.7 +/- 0.5 to 5.0 +/- 1.1 mmHg ml-1 min-1 after NOLA (P < 0.01), with similar percentage increases in both pre- (149 +/- 38%, P < 0.01) and postglomerular (158 +/- 42%, P < 0.01) resistance. 3. Glomerular capillary pressure rose from 33 +/- 1 to 40 +/- 1 mmHg after NOLA (P < 0.01) but despite this, glomerular filtration rate (GFR) and single nephron glomerular filtration rate did not significantly change. 4. Blood pressure increased 18 +/- 1 mmHg (P < 0.001) within 10 min of NOLA administration and remained near this level for the next 90 min. 5. The glomerular ultrafiltration coefficient (Kf) decreased significantly from 0.085 +/- 0.022 to 0.035 +/- 0.006 nl s-1 mmHg-1 (P < 0.05). 6. Urine flow and sodium excretion increased markedly (26 +/- 9 to 337 +/- 102 microliters min-1 and 5 +/- 2 to 342 +/- 12 mumol min-1 respectively, (P < 0.001)) and sodium fractional excretion rose from 1.0 +/- 0.3 to 8.0 +/- 2.2% (P < 0.01). 7. Thus, administration of NOLA to rabbits caused vasoconstriction of both pre- and postglomerular vessels, diuresis and natriuresis without significant change in GFR, and a reduction in Kf. The results suggest that NO may play an important role in the regulation of renal haemodynamics and glomerular function.
K M Denton; W P Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  475     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-23     Completed Date:  1994-06-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-67     Citation Subset:  IM    
Baker Medical Research Institute, Prahran, Victoria, Australia.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Blood Pressure / drug effects,  physiology
Diuresis / drug effects
Glomerular Filtration Rate / drug effects,  physiology
Heart Rate / drug effects,  physiology
Kidney Glomerulus / drug effects,  physiology*
Natriuresis / drug effects
Nitric Oxide / antagonists & inhibitors,  biosynthesis,  physiology*
Renal Circulation / drug effects,  physiology*
Vascular Resistance / drug effects
Reg. No./Substance:
10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 74-79-3/Arginine

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