Document Detail


Intrarenal blood flow distribution in dog kidney determined by 99mTc microaggregates and 201Tl.
MedLine Citation:
PMID:  3202212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrarenal distribution of blood flow was assessed with radioactive albumin microaggregates (MA) in three cortical zones of the dog kidney. The experimentally obtained zonal fractions of total renal blood flow were compared with predicted zonal blood flow fractions obtained in a mathematical model. The maximal degree of skimming that could possibly occur in a single experiment was estimated. The analysis showed that local blood flow in the inner cortical zone was maximally underestimated by 17% because of skimming of MA, and in the outer cortical zone the blood flow was maximally overestimated by 13% with the method of radioactive MA uptake. Renal uptake of 201Tl was measured simultaneously in exactly the same locations. Paired measurements of intrarenal blood flow distribution by MA and Tl uptake methodologies showed that local blood flow assessed with MA in the inner cortical zone was significantly lower than that obtained with 201Tl and that a higher blood flow rate was obtained in the outer cortical zone with MA compared with 201Tl. This disparity could be accounted for by the effect of skimming of MA as predicted by the model.
Authors:
U Abildgaard; O Amtorp; J Gyring; G Daugaard; B Larsen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  255     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1535-41     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Gentofte Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Dogs
Female
Kidney / anatomy & histology,  radionuclide imaging*
Male
Renal Circulation*
Serum Albumin
Technetium / diagnostic use*
Thallium Radioisotopes / diagnostic use*
Chemical
Reg. No./Substance:
0/Serum Albumin; 0/Thallium Radioisotopes; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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