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Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers.
MedLine Citation:
PMID:  12715116     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows: (1) intrarenal artery injection of L-arginine (0.05, 0.24, and 0.48 mmol/kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0.11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3.75 micromol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.
Authors:
Hui-Juan Ma; Yi-Xian Liu; Yu-Ming Wu; Rui-Rong He
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sheng li xue bao : [Acta physiologica Sinica]     Volume:  55     ISSN:  0371-0874     ISO Abbreviation:  Sheng Li Xue Bao     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  20730130R     Medline TA:  Sheng Li Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Affiliation:
Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, PR China.
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