Document Detail

Intrarenal action of angiotensin II in restoring renal artery pressure after acute renal artery stenosis.
MedLine Citation:
PMID:  729209     Owner:  NLM     Status:  MEDLINE    
1. The renal artery of conscious dogs was acutely narrowed over 30 s to reduce renal artery pressure distal to the stenosis to 40 mmHg and the stenosis was maintained for 1 h. The distal renal artery pressure was rapidly restored to a plateau slightly below pre-stenosis values within 10--15 min. Rises in systemic blood pressure and plasma renin activity were small and transient. 2. This restoration was an active process, mediated by the intrarenal effects of angiotensin II (AII), since it was greatly diminished or abolished when the renal artery was narrowed in the presence of angiotensin I-converting enzyme inhibitor or angiotensin receptor antagonist (1-Sar-8-Ile AII). However, it was not diminished by 'total' autonomic effector blockade. 3. This angiotensin II-mediated restoration of renal artery pressure may be of homeostatic significance for the maintenance of glomerular filtration rate.
W P Anderson; P I Korner; C I Johnston; J A Angus; D J Casley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  5     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1978 Sep-Oct
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  529-33     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / blood,  physiology*
Blood Pressure*
Glomerular Filtration Rate
Kidney / physiology
Renal Artery Obstruction
Renin / blood
Saralasin / pharmacology
Teprotide / pharmacology
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 35115-60-7/Teprotide; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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