Document Detail

Intrapulmonary solitary fibrous tumor diagnosed by immunohistochemical and genetic approaches: report of a case.
MedLine Citation:
PMID:  17468826     Owner:  NLM     Status:  MEDLINE    
Although solitary fibrous tumors (SFTs) of the pleura are not uncommon, intrapulmonary SFTs are extremely rare. A 72-year-old woman was admitted to our hospital for an investigation of an enlarging intrapulmonary tumor. Because a definitive diagnosis could not be readily established, a pulmonary wedge resection under video-assisted thoracic surgery was performed. Grossly, the tumor was white, well circumscribed, and separate from the pleural surface. Histologically, it consisted of spindle cells proliferating in a vague fascicular pattern, with many dilated capillaries, and intermingled glandular components. These findings suggested a differential diagnosis that included SFT and nonchondromatous pulmonary hamartoma. On immunohistochemical analysis, the spindle cells showed a strong positive reaction to the CD34 antigen. Interphase fluorescent in situ hybridization revealed an absence of HMGA-1 and -2 translocations. These results supported a diagnosis of SFT. A genetic approach may therefore be useful in the differentiation of SFT from nonchondromatous hamartoma.
Motoyasu Sagawa; Yoshimichi Ueda; Fujitsugu Matsubara; Hiroshi Sakuma; Yutaka Yoshimitsu; Hirokazu Aikawa; Katsuo Usuda; Hiroshi Minato; Tsutomu Sakuma
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-04-30
Journal Detail:
Title:  Surgery today     Volume:  37     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  423-5     Citation Subset:  IM    
Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan.
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MeSH Terms
Diagnosis, Differential
In Situ Hybridization, Fluorescence*
Lung Neoplasms / diagnosis*,  pathology
Neoplasm Invasiveness
Neoplasms, Fibrous Tissue / diagnosis*,  pathology
Thoracic Surgery, Video-Assisted

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