Document Detail


Intrapulmonary shunting in primary pulmonary hypertension: an observation in two patients treated with epoprostenol sodium.
MedLine Citation:
PMID:  9674493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous intravenous infusion of epoprostenol sodium in selected patients with primary pulmonary hypertension improves symptoms and survival. This report describes two patients with primary pulmonary hypertension treated with epoprostenol in whom intrapulmonary shunting and severe hypoxemia occurred. Intrapulmonary shunting was confirmed by contrast echocardiography showing delayed appearance of bubbles in the left cardiac chambers after peripheral venous injection of agitated saline solution.
Authors:
P F Castro; R C Bourge; D C McGiffin; R L Benza; P Fan; N B Pinkard; M D McGoon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  114     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-05     Completed Date:  1998-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, The University of Alabama at Birmingham, 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Anoxia / etiology
Antihypertensive Agents / administration & dosage,  therapeutic use*
Contrast Media / administration & dosage
Echocardiography
Epoprostenol / administration & dosage,  therapeutic use*
Hemangioma, Capillary / pathology
Humans
Hypertension, Pulmonary / drug therapy,  physiopathology*
Infusions, Intravenous
Injections, Intravenous
Lung Neoplasms / pathology
Lung Transplantation
Male
Middle Aged
Pulmonary Circulation / drug effects,  physiology*
Pulmonary Fibrosis / pathology
Sodium Chloride / administration & dosage,  diagnostic use
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Contrast Media; 35121-78-9/Epoprostenol; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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