| Intraplaque hemorrhage in symptomatic intracranial atherosclerotic disease. | |
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MedLine Citation:
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PMID: 19909397 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Studies in patients with extracranial carotid disease have shown that high-resolution magnetic resonance direct thrombus imaging (MRDTI) can reliably identify intraplaque hemorrhage, which may be a better predictor of clinical events than traditional radiographic methods such as percent stenosis. We present the use of high-resolution magnetic resonance imaging for the detection of intraplaque hemorrhage in the intracranial arteries. METHODS: High-resolution 3 Tesla MRDTI was performed using T1-weighted scans with an inversion pulse to null the signal from blood. Abnormal intraplaque T1 signal compatible with hemorrhage or blood products was defined as equal to or higher than 150% of T1 signal of adjacent muscle. RESULTS: The symptomatic middle cerebral artery demonstrated intraplaque signal higher than 150% of the muscle signal in two central slices, consistent with the imaging characteristics of intraplaque hemorrhage demonstrated in extracranial carotid arteries. CONCLUSIONS: High-resolution MRDTI of intracranial atherosclerotic lesions could provide a surrogate marker of plaque activity in vivo and could lead to improvements in risk stratification and treatment of this common disease. |
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Authors:
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Tanya N Turan; Leonardo Bonilha; Paul S Morgan; Robert J Adams; Marc I Chimowitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
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Languages: eng Pagination: e159-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 by the American Society of Neuroimaging. |
Affiliation:
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From the Departments of Neurosciences (TNT, LFB, RJA, MIC) and Radiology and Radiological Science (PSM), Medical University of South Carolina, Charleston, SC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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