| Intrapituitary cell-cell communication regulates ACTH secretion. | |
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MedLine Citation:
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PMID: 2559345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure of rat anterior pituitary cells in culture to a cytotoxin specific for CRF-target cells is followed by increased basal ACTH secretion from the remaining cells three days after the last exposure to the cytotoxin. When CRF-target-depleted populations are co-cultured with unexposed pituitary cells ACTH secretion is more than double that predicted in the absence of cell-to-cell interaction. These data provide evidence for an intrapituitary cell-to-cell signalling system modulating ACTH secretion. |
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Authors:
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J Schwartz; B Canny; W W Vale; J W Funder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroendocrinology Volume: 50 ISSN: 0028-3835 ISO Abbreviation: Neuroendocrinology Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-03-07 Completed Date: 1990-03-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0035665 Medline TA: Neuroendocrinology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 716-22 Citation Subset: IM |
Affiliation:
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Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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secretion* Animals Cell Communication / physiology* Cells, Cultured Corticotropin-Releasing Hormone / analogs & derivatives, pharmacology, physiology Male Pituitary Gland, Anterior / cytology*, drug effects, secretion Plant Proteins / pharmacology Protein Synthesis Inhibitors / pharmacology Rats Rats, Inbred Strains Ribosome Inactivating Proteins, Type 1 |
| Grant Support | |
ID/Acronym/Agency:
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AM26741/AM/NIADDK NIH HHS; HL06808/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Plant Proteins; 0/Protein Synthesis Inhibitors; 0/Ribosome Inactivating Proteins, Type 1; 114308-86-0/corticotropen-releasing hormone, Nle(21,38)-Arg(36)-; 75037-46-6/GEL protein, Gelonium multiflorum; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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