| Intraperitoneal murine Echinococcus multilocularis infection induces differentiation of TGF-β expressing DCs that remain immature. | |
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MedLine Citation:
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PMID: 21609335 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Intraperitoneal larval infection (alveolar echinococcosis, AE) with Echinococcus multilocularis in mice impairs host immunity. Metacestode metabolites may modulate immunity putatively via dendritic cells. During murine AE, a relative increase of peritoneal DCs (pe-DCs) in infected mice (AE-pe-DCs; 4% of total peritoneal cells) as compared to control mice (naïve pe-DCs; 2%) became apparent in our study. The differentiation of AE-pe-DCs into TGF-β-expressing-cells and the higher level of IL-4 than IFN-γ/IL-2 mRNA-expression in AE-CD4+pe-Tcells indicated a Th2-orientation. Analysis of major accessory-molecule-expression on pe-DCs from AE-infected mice revealed that CD80 and CD86 were down regulated on AE-pe-DCs, while ICAM-1(CD54) remained practically unchanged. Moreover, AE-pe-DCs had a weaker surface expression of MHC-classII(Ia)-molecules as compared to naïve pe-DCs. The gene-expression-level of molecules involved in MHC-classII(Ia)-synthesis and formation of MHC-classII(Ia)-peptide complexes were down-regulated. In addition, metacestodes excreted/secreted (E/S) or vesicle-fluid (V/F) antigens were found to alter MHC-class-II-molecule-expression on the surface of BMDCs. Finally, conversely to naïve pe-DCs, an increasing number of AE-pe-DCs down-regulated ConA-induced proliferation of naïve CD4+pe-Tcells. These findings altogether suggested that TGF-β-expressing immature AE-pe-DCs might play a significant role in the generation of a regulatory immune response within the peritoneal cavity of AE-infected mice. |
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Authors:
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N Mejri; J Müller; B Gottstein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-24 |
Journal Detail:
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Title: Parasite immunology Volume: - ISSN: 1365-3024 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910948 Medline TA: Parasite Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Institute of Parasitology, University of Berne, Länggass-Strasse 122, CH-3012 Bern, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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