| Intraperitoneal immunoglobulin (IG) treatment in prophylaxis of bacterial peritonitis in CAPD. | |
| | |
MedLine Citation:
|
PMID: 3329538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate peritoneal immunological defences and to find a possible cure for alterations in the mechanism, we studied the capacity of peritoneal dialysis effluent (PDE) to opsonize bacteria and the phagocytic activity of peritoneal macrophages (PM). Subjects were 40 uremic patients followed for a mean period of 36 months and 40 normal women who underwent laparoscopy (Controls). Opsonic capacity for S.epidermidis of undiluted PDE from CAPD patients with low peritonitis occurrence (LPI) proved similar to that of 10% control serum. It was, however, noticeably inferior when patients were of high peritonitis incidence (HPI). In these cases IgG concentration in PDE was lower than in patients of LPI. A significant correlation was revealed between opsonization capacity for bacteria and IgG concentration values in PDE. We found inverse correlation between opsonic capacity of PDE and number of episodes of peritonitis. Phagocytic capacity of PM from CAPD patients was similar to that of control PM when microorganisms were preopsonized by control serum. Intraperitoneal Immunoglobulin treatment raised PDE opsonization capacity and lowered peritonitis incidence in patients of previously HPI, thus demonstrating the importance of abnormal organization in CAPD peritonitis and the possibility of preventing infections by intraperitoneal Immunoglobulin treatment. These prevention results do not occur with intravenous Immunoglobulin treatment. |
| | |
Authors:
|
S Lamperi; S Carozzi; M G Nasini |
Related Documents
:
|
16862478 - A novel method of ninth-intercostal microlaparoscopic approach for patients with previo... 21787158 - Coenzyme q(10) and its relation with oxidant and antioxidant system markers in patients... 10692278 - A multicenter study of noncompliance with continuous ambulatory peritoneal dialysis exc... 11812938 - Unexpected gynecologic neoplasms in patients with proven or suspected brca-1 or -2 muta... 10379478 - Dysplastic changes in gastric fundic gland polyps of patients with familial adenomatous... 12578748 - Comparison between color duplex ultrasonography and histology of the temporal artery in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biomaterials, artificial cells, and artificial organs Volume: 15 ISSN: 0890-5533 ISO Abbreviation: Biomater Artif Cells Artif Organs Publication Date: 1987 |
Date Detail:
|
Created Date: 1988-06-16 Completed Date: 1988-06-16 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8802605 Medline TA: Biomater Artif Cells Artif Organs Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 151-9 Citation Subset: IM |
Affiliation:
|
Nephrology Division, St. Martin Hospital, Genova, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacterial Infections
/
prevention & control* Escherichia coli Infections / prevention & control Humans Immunization, Passive* Immunoglobulins / administration & dosage Macrophages / immunology Opsonin Proteins / immunology Peritoneal Cavity / immunology Peritoneal Dialysis, Continuous Ambulatory / adverse effects* Peritoneal Lavage Peritonitis / prevention & control* Staphylococcal Infections / prevention & control Staphylococcus epidermidis |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulins; 0/Opsonin Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Applications of artificial cells in medicine and biotechnology.
Next Document: Adsorption of immunologically relevant molecules--its present and future.