| Intraperitoneal cell movement during abdominal carbon dioxide insufflation and laparoscopy. An in vivo model. | |
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MedLine Citation:
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PMID: 8831549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Possible mechanisms of movement of malignant cells within the peritoneal cavity during CO2 insufflation and laparoscopy involve direct transfer via laparoscopic instruments or dispersion of cells by CO2 or water vapor. An in vivo model has been developed to study these mechanisms. METHODS: Laparoscopy was performed on an animal model (domestic white pig). Cells derived from colorectal cancer cell line Lim 1215 were injected to lie free within the peritoneal cavity. A polycarbonate filter system with a 5-micron pore diameter was used to examine CO2 expelled from the peritoneal cavity, during laparoscopy and manipulation of abdominal viscera, for malignant cells. Laparoscopic instruments and laparoscopic ports were washed independently, and fluid was centrifuged and examined for malignant cells. RESULTS: Malignant cells were identified on 1 of 30 filters used to examine exhaust carbon dioxide. Malignant cells also were identified from 2 of 10 washings from laparoscopic ports and from 4 of 10 washings of laparoscopic instruments. CONCLUSIONS: These results suggest that movement of cells throughout the peritoneal cavity during laparoscopy is via contaminated instruments, but local cell movement by dispersion possibly within water vapor from the port may also occur. |
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Authors:
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P J Hewett; W M Thomas; G King; M Eaton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 39 ISSN: 0012-3706 ISO Abbreviation: Dis. Colon Rectum Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-01 Completed Date: 1996-11-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S62-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Queen Elizabeth Hospital, Woodville, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / cytology* Carbon Dioxide Cell Movement Colectomy / adverse effects* Colorectal Neoplasms Disease Models, Animal Equipment Contamination Filtration Humans Laparoscopy / adverse effects* Neoplasm Seeding* Pneumoperitoneum, Artificial / adverse effects* Swine Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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