Document Detail

Intraperitoneal, but not subcutaneous, administration of the sulphated cholecystokinin octapeptide (CCK-8S) inhibits operant and nonoperant food intake in rats: implications for the CCK-satiety hypothesis.
MedLine Citation:
PMID:  10389118     Owner:  NLM     Status:  MEDLINE    
The effects of administering CCK-8S by the subcutaneous (s.c.) and intraperitoneal (i.p.) routes were investigated on both operant and nonoperant food intake in rats that had been fasted for 22 h. Intraperitoneal administration of CCK-8S (5 micrograms/kg) significantly reduced both operant and nonoperant food intake. In contrast, CCK-8S (5-50 micrograms/kg) administered s.c. had no effects on food intake in both types of behavioral paradigms. The results show that the peripheral route of administration of CCK-8S is an important factor to be taken into consideration when investigating its effects on food intake. The results are discussed in terms of the hypothesis that CCK released from the small intestine during a meal acts in a paracrine fashion to produce satiety.
I S Ebenezer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  21     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, England.
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MeSH Terms
Appetite Depressants / pharmacology
Eating / drug effects*
Injections, Intraperitoneal
Injections, Subcutaneous
Intestine, Small / metabolism*
Nootropic Agents / administration & dosage*,  pharmacology
Paracrine Communication / physiology
Rats, Wistar
Satiety Response / physiology*
Sincalide / administration & dosage,  analogs & derivatives*,  pharmacology,  secretion
Reg. No./Substance:
0/8-sulfocholecystokinin octapeptide; 0/Appetite Depressants; 0/Nootropic Agents; 25126-32-3/Sincalide

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