| Intraperitoneal, but not subcutaneous, administration of the sulphated cholecystokinin octapeptide (CCK-8S) inhibits operant and nonoperant food intake in rats: implications for the CCK-satiety hypothesis. | |
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MedLine Citation:
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PMID: 10389118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of administering CCK-8S by the subcutaneous (s.c.) and intraperitoneal (i.p.) routes were investigated on both operant and nonoperant food intake in rats that had been fasted for 22 h. Intraperitoneal administration of CCK-8S (5 micrograms/kg) significantly reduced both operant and nonoperant food intake. In contrast, CCK-8S (5-50 micrograms/kg) administered s.c. had no effects on food intake in both types of behavioral paradigms. The results show that the peripheral route of administration of CCK-8S is an important factor to be taken into consideration when investigating its effects on food intake. The results are discussed in terms of the hypothesis that CCK released from the small intestine during a meal acts in a paracrine fashion to produce satiety. |
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Authors:
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I S Ebenezer |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Methods and findings in experimental and clinical pharmacology Volume: 21 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-08-31 Completed Date: 1999-08-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 167-71 Citation Subset: IM |
Affiliation:
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Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, England. ivor.ebenezer@port.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Depressants / pharmacology Eating / drug effects* Injections, Intraperitoneal Injections, Subcutaneous Intestine, Small / metabolism* Male Nootropic Agents / administration & dosage*, pharmacology Paracrine Communication / physiology Rats Rats, Wistar Satiety Response / physiology* Sincalide / administration & dosage, analogs & derivatives*, pharmacology, secretion |
| Chemical | |
Reg. No./Substance:
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0/8-sulfocholecystokinin octapeptide; 0/Appetite Depressants; 0/Nootropic Agents; 25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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