Document Detail


Intraperitoneal 131I- and 111In-791T/36 monoclonal antibody in recurrent ovarian cancer: imaging and biodistribution.
MedLine Citation:
PMID:  2812640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following administration and before and after peritoneal lavage at 48 h. Blood levels of both preparations rose over the first 20-40 h reaching 8-14% of the administered dose in the circulation and then declined (T1/2 of 40 h). Circulating radiolabel was still attached partially to antibody as shown by precipitation with anti-mouse IgG antiserum. The rapid appearance of radiolabel in the bloodstream meant that any tumour localization could be from circulating antibody rather than local infiltration. Interpretation of the images was difficult and the distribution of the tracer was different from that previously observed using i.v. administration of antibody. In some cases the images were confusing and the uptake of activity did not fit in with the clinical knowledge of the disease or the findings from laparoscopy. Tumour specimens resected at 4-5 days showed up to 0.02% of the dose g-1.
Authors:
A C Perkins; M V Pimm; C Gie; R A Marksman; E M Symonds; R W Baldwin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  10     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-84     Citation Subset:  IM    
Affiliation:
Medical Physics Department, University Hospital, Nottingham, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal / administration & dosage,  pharmacokinetics*
Antibodies, Neoplasm / administration & dosage,  pharmacokinetics*
Cystadenocarcinoma / metabolism,  radiotherapy
Female
Humans
Indium Radioisotopes / administration & dosage,  pharmacokinetics*
Injections, Intraperitoneal
Iodine Radioisotopes / administration & dosage,  pharmacokinetics*,  therapeutic use
Middle Aged
Neoplasm Recurrence, Local
Ovarian Neoplasms / metabolism,  radiotherapy*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Neoplasm; 0/Indium Radioisotopes; 0/Iodine Radioisotopes

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