Document Detail

Intrapericardial fibrinolytic therapy in purulent pericarditis.
MedLine Citation:
PMID:  12204726     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Purulent pericarditis is a rare disease that is being conventionally managed with intravenous antibiotics and pericardial drainage. In our study, we used intrapericardial fibrinolytic treatment together with pericardiocentesis and antibiotic therapy. We evaluated the role of intrapericardial fibrinolytic treatment in nine purulent pericarditis patients. METHODS: Six children and three adult patients with purulent pericarditis, aged between 5 and 50 years, were treated with intrapericardial fibrinolysis by streptokinase. Intrapericardial drainage catheter was placed into the subxyphoidal localization under local anaesthesia and echocardiography guidance, streptokinase was infused into the pericardial sac as the fibrinolytic agent. RESULTS: Repeat echocardiograms showed no reaccumulation of pericardial effusions, pericardial thickening or constrictions. No patients had systemic bleeding, arrhythmias, or hypotension. There was one death which was due to sepsis and congestive heart failure. CONCLUSION: We believe that early pericardial drainage and intrapericardial fibrinolysis appears to be safe and effective in the treatment of purulent pericarditis.
Haşim Ustünsoy; Mehmet Adnan Celkan; Muammer Cumhur Sivrikoz; Hakki Kazaz; Metin Kilinç
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  22     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2002-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  373-6     Citation Subset:  IM    
Department of Cardiovascular and Thoracic Surgery, Gaziantep University School of Medicine, Gögcaron;üs ve Kalp Damar Cerrahisi Anabilimdali, Kolejtepe, Gaziantep, Turkey.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Child, Preschool
Fibrinolytic Agents / administration & dosage*
Middle Aged
Pericarditis / drug therapy*,  therapy,  ultrasonography
Staphylococcal Infections / drug therapy*,  therapy
Streptokinase / administration & dosage*
Thrombolytic Therapy*
Vancomycin / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Fibrinolytic Agents; 1404-90-6/Vancomycin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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